Session: SUN 257-280-Disorders of Vitamin D Metabolism & Action
Poster Board SUN-268
Objective: To evaluate the effects of high dose of vitamin D supplementation for one year on cytokine, inflammatory and thrombotic parameters as well as IGF-1 levels in people with pre-diabetes and low levels of vitamin D.
Experimental Procedures: In Latino and African American subjects ≥40 years old, pre-diabetes was diagnosed by a 2 hr glucose level of 140-199 mg/dL and/or FPG 110-125 mg/dL.109 subjects had serum 25-OH vitamin D levels < 30 ng/mL and prediabetes and were randomized to either receive vitamin D (mean 88,865 IU/ week) (n=56) or placebo oil (n=53) for one year. Serum samples were collected at baseline, 6, 9 and 12 months for measurements of inflammatory cytokines IL6, TNFα, C-reactive protein (CRP) and PAI-1 and IGF-1 from 40 randomly selected subjects in each group.
Results: Serum 25-OH vitamin D levels of 20 ng/mL quickly rose to nearly 70 ng/mL in those receiving vitamin D and did not change in the placebo group. Two-way repeated measure ANOVA showed that there were no differences between the 2 groups in any of the five selected parameters: TNFα (P=0.43); CRP (P=0.31); IL6 (P=0.67); PAI-1 (P=0.14); and IGF-1 (P=0.88).
Conclusion: High dose vitamin D supplementation in subjects with pre-diabetes and hypovitaminosis D for one year failed to affect levels of inflammatory cytokines, markers of inflammation, as well as PAI 1, and IGF-1.
Nothing to Disclose: IS, PD, RS, ML, TCF, MBD
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