Disturbed balance and increased fear of falling in acromegalic patients

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 88-129-Acromegaly & Prolactinoma
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-122
Aysegul Atmaca*, Berna Tander, Elif Kilic Kan, Yasemin Ulus, Gulcin Cengiz Ecemis, Yesim Akyol and Leman Tomak
Ondokuz Mayis University School of Medicine, Samsun, Turkey
Introduction: Falls and disturbances in balance may be seen more commonly in acromegalic patients than normal population. No studies have been conducted to evaluate balance in acromegalic patients.  The aim of this study is to evaluate balance and fear of falling in acromegalic patients and relation of balance with disease characteristics. 
Materials and methods: Forty-eight patients with acromegaly and 41 age-matched controls were enrolled in the study. Beck depression scale (BDS) and Beck anxiety scale (BAS) were used to evaluate psychological status of the groups.  Berg balance scale (BBS), one-leg stance test (OLST) and 50 meters walking test were used to compare balance and falls efficacy scale-international (FES-I) was used to compare fear of falling between the groups.
Results: The median age of the patient group was 48 (25-75) years and control group was 50 (25-67) years. The median disease duration in patients was 4 (1-31) years. Age, gender, body mass index and educational status were not different between the groups. Diabetes mellitus, hypertension, malignancy, arthropathy, carpal tunnel syndrome and anemia were more prevalent in acromegalic patients than controls. The prevalences of dyslipidemia, osteoporosis, cardiomyopathy and obstructive sleep apnea were not different (p > 0.005). BDS and BAS scores were similar between the groups. Regarding the balance; BBS score was lower and 50 meter walking time was greater in patients than controls. There was no difference in OLST between the groups. FES-I score was higher in patients than controls.  BBS score and OLST was negatively and FES-I was positively correlated with age. FES-I was negatively correlated with BBS score and OLST was positively correlated with 50 meters walking test, as expected. Neither balance tests nor FES-I were correlated with disease duration and IGF-1 levels.  Logistic regression analysis revealed that BBS was not affected by the presence of co-morbidities, postoperative vision loss and remission status.
Discussion: This is the first study showing that balance is disturbed in acromegalic patients and this may lead to fear of falling. This disturbance is not related to disease duration, psychological status and co-morbidities. Acromegalic patients should be evaluated for balance regardless of their time of diagnosis. More studies of balance including proprioception tests are needed  to confirm these results.

Nothing to Disclose: AA, BT, EKK, YU, GCE, YA, LT

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