Neuropeptide Y and Anti-mullerian hormone in the peri-and postmenopause, its possible association with vasomotor symptoms

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SAT 498-531-Female Repro Endocrinology & Case Reports
Clinical
Saturday, June 15, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SAT-531
Norma Aguilera*
Universidad de Guanajuato, irapuato
Neuropeptide Y and Anti-mullerian hormone in the peri-and postmenopause, its possible association with vasomotor symptoms.

Norma Lilia Aguilera-Elizarraraz1 and Juan Manuel Malacara2. 1Departamento de Enfermería y Obstetricia, División Ciencias de la Vida, Campus Irapuato- Salamanca,  2Departamento de Ciencias Médicas. División Ciencias de la Salud. Campus León. Universidad de Guanajuato.

Introduction.  Hot flashes are important symptoms that affect womens quality of life at postmenopause. The mechanism of this symptom is not well understood.

Aim.  To study the possible influence of neuropeptide Y (NPY), Anti-mullerian hormone (AMH), , follicle stimulating hormone (FSH), 17 b-estradiol (E2) on vasomotor symptoms in peri-and postmenopausal women.

Methodology.  In a population based cross-sectional study we studied 108 peri-and postmenopausal women 40 to 60 years of age. We collected vasomotor and other frequent menopausal symptoms. Fasting blood levels were obtained to measure NPY, FSH, E2 and AMH. We compared frequency of symptoms, clinical parameters and hormone levels in peri-and postmenopausal groups by Student t test and chi2 test. We carried out a stepwise multiple regression to compare the factors associated with symptoms and as candidate regressors age, schooling, BMI, parity, time since menopause and FSH, E2, NPY and AMH levels.

Results.  In a sample of 108 women, 61 at perimenopause and 47 at postmenopause. Women at postmenopause had a marginally higher rate of hot flashes (p <0.037). Serum AMH (p <0.01), and E2 were lower (p <0.001) and FSH (p <0.02) had increased levels at postmenopause. NPY had similar levels in both groups. In the study of factors associated with NPY, we found it negatively associated with schooling (P<.007) and parity (p<.04) and positively with HDL-cholesterol levels (p<.02). Duration of hot flashes were positively associated with sleep problems (p<.006), FSH levels (p<.005) and BMI (p<.04). AMH was not associated with symptoms or other hormones.

Conclusion. We did not find NPY associated with hot-flashes of with other symptom at menopause. Its main association with schooling, may be interpreted to result from a chronic stress response.

Keywords: Neuropeptide Y, AMH, FSH, Estradiol.

Nothing to Disclose: NA

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm

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