Effect of Maternal Bariatric Surgery on Metabolic Parameters of Offspring

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SAT 708-722-Obesity: Response to Interventions
Basic
Saturday, June 15, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SAT-713
Bernadette Elizabeth Grayson*1, Katarina M Schneider2, Stephen C Woods3 and Randy J Seeley4
1University of Cincinnati, Cincinnati, OH, 2University of Cincinnati, 3Univ of Cincinnati Med Ctr, Cincinnati, OH, 4Univ of Cincinnati, Cincinnati, OH
More than 25% of women of childbearing age in the US are obese, having a BMI ≥ 30. Obesity has profound negative consequences on a number of aspects of female reproduction as well as the metabolic health of the offspring. While weight loss improves many complications, long-term durable weight loss is difficult to achieve. Whereas pharmacologic treatments result in only small reductions in body-weight, several bariatric surgical procedures produce sustained body-weight reduction in obese individuals. Although the benefits of these procedures to the recipient are obvious, a key question remains concerning the impact on their offspring.

The purpose of these studies was to investigate the impact of maternal vertical sleeve gastrectomy (VSG), a commonly used bariatric procedure, on the metabolic health of offspring born following surgery. We hypothesized that maternal weight loss would confer benefit to offspring born following VSG in comparison to control offspring born to obese females.  Female Long Evans rats were maintained on either a low-fat chow (10% fat calories) or a palatable high-fat diet (HFD) (40% butter fat calories) prior to VSG or sham surgery.

At birth, offspring of VSG dams (oVSG) were significantly lighter and shorter than offspring born to either dams on Chow or dams on HFD having received sham-operations (oChow and oHFD), respectively. At weaning, oVSG animals were glucose intolerant in comparison to either oChow or oHFD. Circulating plasma triglycerides were significantly elevated in oVSG and oHFD in comparison to oChow. Staining of the liver with Oil Red O revealed ectopic lipid accumulation in both oHFD and oVSG with total liver triglyceride content being greatest in oVSG. When maintained on a HFD following puberty, oVSG adult offspring had greater propensity to develop glucose intolerance and increased adiposity than offspring from Chow and HFD-fed control dams.  

Collectively these data suggest that maternal loss of adiposity following VSG surgery while continuously maintained on HFD does not confer a metabolic benefit to the offspring during postnatal development as well as into adulthood in the measures we investigated.

Disclosure: RJS: Board Member, Johnson &Johnson, Investigator, Johnson &Johnson, Consultant, Novo Nordisk, Investigator, Novo Nordisk. Nothing to Disclose: BEG, KMS, SCW

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm

Sources of Research Support: The work of the laboratory is supported in part by NIH Awards DK56863, DK57900, U01CA141464, DK082480, MH069860, DK082480 and also work with Ethicon Endo-Surgery Inc., F. Hoffman-La Roche Ltd., Pfizer Inc. and Novo Nordisk A/S. BEG is also supported by NIH Award 1F32HD68103.