Session: SAT 708-722-Obesity: Response to Interventions
Poster Board SAT-713
The purpose of these studies was to investigate the impact of maternal vertical sleeve gastrectomy (VSG), a commonly used bariatric procedure, on the metabolic health of offspring born following surgery. We hypothesized that maternal weight loss would confer benefit to offspring born following VSG in comparison to control offspring born to obese females. Female Long Evans rats were maintained on either a low-fat chow (10% fat calories) or a palatable high-fat diet (HFD) (40% butter fat calories) prior to VSG or sham surgery.
At birth, offspring of VSG dams (oVSG) were significantly lighter and shorter than offspring born to either dams on Chow or dams on HFD having received sham-operations (oChow and oHFD), respectively. At weaning, oVSG animals were glucose intolerant in comparison to either oChow or oHFD. Circulating plasma triglycerides were significantly elevated in oVSG and oHFD in comparison to oChow. Staining of the liver with Oil Red O revealed ectopic lipid accumulation in both oHFD and oVSG with total liver triglyceride content being greatest in oVSG. When maintained on a HFD following puberty, oVSG adult offspring had greater propensity to develop glucose intolerance and increased adiposity than offspring from Chow and HFD-fed control dams.
Collectively these data suggest that maternal loss of adiposity following VSG surgery while continuously maintained on HFD does not confer a metabolic benefit to the offspring during postnatal development as well as into adulthood in the measures we investigated.
Disclosure: RJS: Board Member, Johnson &Johnson, Investigator, Johnson &Johnson, Consultant, Novo Nordisk, Investigator, Novo Nordisk. Nothing to Disclose: BEG, KMS, SCW
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