Session: SUN 807-838-Diabetes - Diagnosis, Complications & Outcomes
Poster Board SUN-818
Methods. A total of 2631 patients with collagen vascular diseases was registered between 1986 and 2006 in the Chiba-Shimoshizu Rheumatic Cohort. We analyzed 681 patients newly treated with high-dose glucocorticoid, who did not have DM and/or its previous diagnosis (age: 46.3±16.7 years, PSL dose: 40.0±14.1 mg/day). GIDM was diagnosed by two or more glucose measurements in patients with fasting glycaemia >7 mmol/l and 120 min post-load glycaemia >11.1 mmol/l.
Results. GIDM was observed in 26.3% within 2 months, and the GIDM group had higher age, higher BMI, lower rates of females and systemic lupus erythematosus, higher rates of smoking, alcohol use and microscopic polyangiitis in comparison with non-GIDM. Multivariate logistic regression analysis demonstrated that the risk of GIDM was independently higher in every 10-year increment of initial age with adjusted odds ratio (OR) 1.556 (95% confidence interval: 1.359-1.783), in every one kg/m2 increment of BMI with OR 1.062 (1.002-1.124), in current smoking with OR 1.664 (1.057-2.622), and in every 10 mg increment of initial dose of prednisolone with OR 1.250(1.074-1.454).
Conclusion. High-dose glucocorticoids caused GIDM with high prevalence within a short period, and current smokers should be considered at higher risk of GIDM in addition to age, BMI, and initial dose.
Nothing to Disclose: IT, TT, TT
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