Session: MON 515-547-Female Reproductive Endocrinology
Poster Board MON-540
In histological specimens processed with peroxidase-immunolabeling, the Inf contained a very dense fiber network immunoreactive to the preprotachykinin A gene product substance P. Quantitative analysis of the lightly-stained cell bodies established a sex difference and identified higher density of labeled perikarya in the Inf of postmenopausal women, compared with age-matched men. Dual-immunofluorescent studies provided evidence for substance P immunoreactivity in a large subset of neurokinin B-immunoreactive axons. In contrast, neurokinin B-immunoreactive axons in the Inf tended not to contain immunoreactive galanin and only rarely contained immunoreactive dynorphin, unlike neurokinin B-immunoreactive axons in the mouse arcuate nucleus. The absence of galanin, infrequent occurrence of dynorphin and frequent expression of substance P immunoreactivity in neurokinin B-immunoreactive fibers in the human Inf represent conspicuous species differences from the mouse and exemplifies the inherent limitations of the rodent models for human reproduction. The functional significance of substance P/neurokinin B colocalization in the human Inf requires clarification.
Nothing to Disclose: EH, BB, KR, LH, PC, SRB, MAG, WSD, ZL
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