Session: SUN 199-233-Bone Biology
Poster Board SUN-224
Methods: Eighty girls (age 9–15 years) were enrolled in the study divided by their BMI standard deviation scores (BMI-SDSs) into 4 groups of 20 girls each: overweight 1.8±0.4; obese 2.2±0.4; morbidly obese 3.6±0.4 and lean controls -0.11±0.4, in whom adipocytokines, hs-CRP and bone markers were measured by means of immunoenzymatic techniques.
Results: The main results of the study showed that: a) OPG, RANKL and bALP levels decreased significantly as BMI-SDSs increased (p=0.03, p=0.03 and p<0.01, respectively), while osteocalcin, CTX and bone TRACP5 show no relations (p>0.60); b) leptin correlated negatively with bALP, bone TRACP-5b, osteocalcin, OPG and RANKL (p<0.05, p=0.02 and p=0.006, respectively); adiponectin correlated positively with CTX and OPG (p=0.004 and p=0.04, respectively); RBP-4 correlated positively with OPG and bALP (p<0.01 and p=0.002, respectively), while lipocalin-2 correlated positively with bALP (p<0.001); c) obesity-related systemic inflammation expressed as hs-CRP correlated positively only with OPG.
Conclusion: Our findings suggest that there are important links between adipose tissue-derived proteins and bone remodeling factors. Bone turnover was altered in obese girls mainly due to decreased OPG levels. There were significant correlations of OPG with leptin, adiponectin and hs-CRP, indicating that, probably, the bone mass is regulated by adipokines, as well as by low grade inflammation in obese children.
1Dimitri et al. Bone 50: 457–466, 2012.
Nothing to Disclose: CK, IP, ET, GPC
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