METABOLIC DISORDERS IN PATIENTS WITH HIRSUTISM

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 498-523-Female Reproductive Endocrinology & Case Reports
Clinical
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-519
Zuleyha Karaca1, Banu Acmaz2, Fatih Tanriverdi1, Kursad Unluhizarci1, Yilmaz Sahin3 and Fahrettin Kelestimur*4
1Faculty of Medicine, Erciyes University, Kayseri, Turkey, 2Erciyes University Medical School Department of Endocrinology, 3Erciyes University Medical School Department of Obstetrics and Gynecology, 4Erciyes University, Kayseri, Turkey
Introduction:Hirsutism is a frequent disorder in women during reproductive age. Our aim was to investigate patients presenting with the main complaint of hirsutism in means of metabolic disorders. 

Materials and Methods: The study was carried out in 146 patients who admitted to Endocrinology Department with the main complaint of hirsutism. All patients were evaluated with serum FSH, LH, estradiol, androgen, SHBG, fasting serum lipid and insulin levels, oral glucose tolerance test and ACTH stimulation test. 

Results: The etiologies of hirsutism were polycystic ovary syndrome (PCOS) in 79%, idiopathic hirsutism in 11%, idiopathic hyperandrogenemia in 7.5% and non-classical congenital hyperplasia in 2.5% of the patients. Patients with idiopathic hirsutism and idiopathic hyperandrogenemia were categorised as functional androgen excess disorders and compared with patients with PCOS. Patients with PCOS had higher total testosterone, androstenedione, 17-OH progesterone levels and 11-deoxycortisol response to ACTH stimulation test. All other hormone levels were similar in two groups. Two groups had similar lipid and glucose levels and similar prevalance of glucose metabolism disorders. Age and body mass index (BMI) were positively correlated with fasting and 120th minute glucose levels following OGTT. When hirsute patients were categorised according to their BMI as normal weight, overweight and obese, increased triglyceride, low HDL-cholesterol, low SHBG and glucose metabolism disorders were found to be more frequent in the overweight and obese patients than normal weight.

Conclusion:Glucose metabolism disorders are seen in idiopathic hirsutism and idiopathic hyperandrogenemia as frequent as PCOS. The most important determinant of insulin resistance and dyslipidemia in hirsute patients is BMI rather than the etiology of hirsutism.

Nothing to Disclose: ZK, BA, FT, KU, YS, FK

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm