Session: SAT 554-583-Male Reproductive Endocrinology & Case Reports
Poster Board SAT-564
Objective: The aim of this study was to investigate testicular function in monorchid boys.
Methods: In a retrospective semi-longitudinal study, we compared serum AMH, testosterone, FSH and LH between 89 monorchid patients (119 samples), ages 1.1-18.7 yr, and 421 normal boys. Only one sample was included in each age group. Comparisons were performed using the Mann Whitney test.
Results: In monorchid boys, AMH (pmol/l, median and interquartile range) was: 6m-2.9 yr: 324 (221-820), 3-9 yr: 403 (203-637), 9-10.9 yr: 330 (196-446), 11-12.9 yr: 165 (62-281), 13-14.9: 48 (30-67), >15 yr: 37 (20-44), showing a significant reduction in all groups except 11-12.9 yr; 34% of the samples were <3rd centile. FSH was significantly elevated in all patients > 13 yr. FSH was >97th centile in 9% of monorchid patients <9 yr and 27% of patients >9 yr. LH was significantly elevated in groups 11-12.9 yr and >15 yr. LH was >97th centile in 22% of monorchid patients <9 yr and 12% of patients > 9 yr. Testosterone was significantly reduced only in monorchid patients 9-12.9 yr; 16% of monorchid patients >13 yr had testosterone <3rd centile. Similar results were observed when the analysis was performed according to Tanner stages. A subgroup of 20 monorchid patients in whom a history compatible with gonadal damage of the remaining testis could be ruled out was analyzed: AMH was significantly reduced as compared to age-matched controls in all groups except the 11-12.9 yr and >15 yr.
Conclusions: AMH reduction and FSH increase indicates that the remaining testis does not compensate the function of the absent one. Furthermore, results in patients with no history compatible with gonadal damage of the remaining testis rule out that reduced AMH is related to the concomitant dysfunction of the remaining testis.
Disclosure: PB: Collaborator, CONICET. RAR: Investigator, Beckman Coulter, Investigator, CONICET. Nothing to Disclose: RPG, CH, MGR, MGB, SEG
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