Session: SUN 839-872-Diabetes & Obesity Management
Poster Board SUN-872
Thirty-seven subjects, randomly selected from patients with type 2 diabetes, were hospitalized and treated with insulin, in combination with microcirculation and trophic nerve therapy for 2 weeks. Post-treatment, patients exhibited excellent glycemic control, with reduction in insulin requirements. The patients were followed up for 6 months to evaluate their long-term islet function improvement. β-cell and α-cell function was assessed. During an OGTT test blood glucose, insulin, glucagon, and C-peptide were measured fasting and at 30, 60 min 120 min, 180 min time points. Fasting HbA1C and GSP were also measured on the same day.
After the 2-week therapy period patients lost 3.4±2.9 kg body weight, glucose area under the curve (AUCG) show significantly reduced by 25.6% (from 62.6 ±10.0 mmol/L/min to 46.6±11.8 mmol/L/min, P < 0.01) and insulin requirements were also significantly reduced by 79.3% (0.29±0.21 units kg-1 day-1 before treatment vs. 0.06±0.01 units kg-1 day-1 after treatment, P < 0.01). During the 6 month follow up, HbA1C and GSP levels were maintained within the normal range. C-peptide area under the curve (AUCC) and the ratio of AUCC to AUCG, indicators of β-cell function, showed significant increases 15.6% and 39.1% separately (P< 0.01). An increase of C-peptide concentration was shown at the 30 min or 60 min time points of the OGTT test (△Cp30/△Glu30 and △Cp60/△Glu60). Furthermore, there was a significant improvement in the homeostasis model assessment (HOMA) sensitivity and HOMA for insulin resistance (HOMA-IR), from 7.66 to 6.69. In addition, patients had greater suppression of plasma glucagon during the OGTT, at the 30 min, 60 min, 120 min and 180 min time points after a meal than at fasting.
In conclusion, this study, for the first time, has demonstrated that a 2-week therapy can restore β-cell and α-cell functions and significantly improve insulin sensitivity in type 2 diabetic patients over a six month period.
Nothing to Disclose: ZW, MAG, NK, HX, QT, FL, TYSR, RY, YSD, LJG, MT, LZ, HM, YW
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