POLYMORPHISMS OF GENES ENCODING FOR ADIPOKINES ARE ASSOCIATED TO THE SUSCEPTIBILITY FOR DIFFERENTIATED THYROID CANCER

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 459-496-Thyroid Neoplasia & Case Reports
Clinical
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-459
Marjory Alana Marcello1, Jacqueline Fatima Martins Almeida1, Lucas Leite Cunha1, Andre Lopes Carvalho2, Ligia Vera Montalli Assumpção1 and Laura Sterian Ward*3
1University of Campinas, Brazil, 2Barretos Cancer Hospital, Brazil, 3University of Campinas, Campinas, Brazil
Background: We previously demonstrated that altered adiponectin, leptin, resitin and ghrelin serum concentrations were associated to an increased risk for Differentiated Thyroid Cancer (DTC) in obese individuals.

Objectives: We aimed to investigate the role of polymorphisms in Adiponectin (ADIPOQ), Leptin (LEP), Resistin (RETN), Ghrelin (GHRL) and their receptors (ADIPOR1, ADIPOR2, LEPR, GHSR) genes in the susceptibility to DTC and patients' clinical features.

Methods: We genotyped 153 DTC patients (130 females, 23 males, 40.87+13.80 years old); and 234 controls (204 females, 30 males, 37.61+13.39 years old) matched for age, gender and Body Mass Index (BMI) using TaqMan SNP Genotyping® assays for 21 polymorphisms in ADIPOQ, ADIPOR1, ADIPOR2, LEP, LEPR, RETN, GHRL and GHSR genes.

Results: Only two (rs3774262 and rs2167270) out of the 21 SNPs were correlated with the serum levels of corresponding adipokines. Individuals with the genotype GG of the rs3774262 presented higher levels (3.21+1.25 µg/ml) of adiponectin than individuals with GA (2.74+1.43 µg/ml) and AA (2.15+0.00 µg/ml) genotypes (p=0.03557); and individuals with the genotype AG of the rs3774262 presented higher levels (10,02+1,35 ng/ml) of leptin than individuals with AA (9,74+1,01 ng/ml) and GG (9,29+1,30 ng/ml) genotypes (p=0.00746). Concerning the ADIPOQ gene, patients with LEP GG genotype (rs 7799039) had larger tumors (2.7+1.0 cm) than patients with AG (2.2+0.7 cm) and AA (1.1+0.4 cm) (p=0.03117). The inheritance of the AA genotype for the LEPR gene (rs 1137101) diminished the risk of DTC when compared to altered individuals (AG or GG) (OR= 0.3915; 95%CI: 0.2084 – 0.7354; p=0.0038). Two polymorphisms in the RETN gene were related to higher BMI levels. The GG genotype of rs1862513 and the CC genotype of the rs3745369 were more frequent among overweight individuals. The inheritance of the wild-type alleles of GHSR genes, both for the rs2232165  and rs572169 SNPs, were protection factors against DTC. Individuals with rs2232165 GG genotype presented less risk of developing DTC than individuals with GA or AA genotypes (OR= 0.2172; 95%CI: 0.0596 – 0.7906; p=0.0151) and individuals with rs572169 CC genotype presented less risk of developing DTC than individuals with CT or TT genotypes (OR= 0.4973; 95%CI: 0.2839 – 0.8714; p=0.0191).

Conclusion: Our results suggest that polymorphisms in adipokines encoding genes are associated to the risk of DTC.

Nothing to Disclose: MAM, JFMA, LLC, ALC, LVMA, LSW

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm

Sources of Research Support: CNPq - National Council for Scientific and Technological Development
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