Association Between Vitamin D Deficiency and Pregnancy Outcomes: A Prospective Population-Based Study in Southern China

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 238-262-Vitamin D Action, Deficiency & Disorders
Bench to Bedside
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-249
Jing Zhou*1, Lei Su1, Min Liu1, Zilian Wang1, Xiaopei Cao1 and Haipeng Xiao2
1The First Affiliated Hospital of Sun Yat-sen University, 2The First Affiliated Hospital of Sun Yat-sen University, Guang Zhou, China
Objective  Observational studies relating circulating 25-hydroxyvitamin D[25(OH)D] and pregnancy outcomes have reported conflicting results. The aim of the study was to assess maternal 25(OH)D status and its association with pregnancy outcomes.

Methods  A prospective population-based study was conducted in Southern China. Pregnant women (n=2960) and healthy controls (n=100) were recruited at a teaching hospital in Guangzhou city between 2010 and 2011. Maternal 25(OH)D levels were measured at 16-20 wk gestation. Demographics and data from the maternal medical record were abstracted. Maternal and fetal adverse outcomes were evaluated.   

Results  Mean 25(OH)D in pregnant women was 27.03±7.92ng/ml. 18.9% of pregnant women had vitamin D deficiency [25(OH)D ≤20 ng/ml] . 48.6% had vitamin D insufficiency[25(OH)D 21-29 ng/ml]. Maternal 25(OH)D was highest in summer and lowest in winter, which showed a

strong positive correlation with temperature (R=0.942) and calcium (R=0.074). Prevalence of gestational diabetes (adjusted odds ratio 1.017; 95% confidence interval  1.002-1.033) and preterm delivery (adjusted odds ratio 1.038; 95% confidence interval  1.018-1.059 ) in sufficiency group was higher than that in deficiency and insufficiency group while other maternal complications (premature rupture of membranes break, oligohydramnios, gestational hypertension, infection, gestational thrombocytopenia), cesarean section, fetal loss, malformations, infant outcomes (birth weight and height, score of Apgar 1’,5’,fetal distress, macrosomia, small for gestational age, asphyxia of newborn) were similar between groups.

Conclusion  We report a high prevalence of vitamin D deficiency and insufficiency among pregnant women in Southern China. Except for high prevalence of gestational diabetes and preterm delivery in subjects with sufficient vitamin D, there were no significant associations between adverse pregnancy outcomes and vitamin D deficiency or insufficiency at 16-20 wk gestation.

Nothing to Disclose: Jing Zhou, Lei Su, Min Liu, Zilian Wang, Xiaopei Cao, Haipeng Xiao.

Nothing to Disclose: JZ, LS, ML, ZW, XC, HX

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm