Session: SUN 758-779-Cardiometabolic Risk & Vascular Biology
Poster Board SUN-769
Methods:Serum IGF-I levels were measured in 2901 elderly men (age 69 to 81 years) included in the prospective population-based MrOS-Sweden. Data for CV events were obtained from central Swedish registers with no loss of follow-up. The statistical analyses included Cox proportional hazards regressions with or without a spline approach.
Results:During the follow-up (median 5.1 yrs) 589 of the participants experienced a CV event. The association between serum IGF-I and risk of CV events was non-linear, and restricted cubic spline Cox regression analysis revealed a U-shaped association between serum IGF-I levels and CV events (p<0.01 for non-linearity). Low as well as high serum IGF-I (quintile 1 or 5 vs. quintiles 2-4) associated with significantly increased risk for CV events (hazard ratio (HR) = 1.25, 95% confidence interval (CI) 1.02-1.54; and HR = 1.35, 95% CI 1.10-1.66, respectively). These associations remained after adjustment for prevalent CV disease and multiple other CV risk factors.
In exploratory post hoc analyses, we examined whether IGF-I was associated with the risk of coronary heart disease (CHD, n=367 events) and/or cerebrovascular (n=273 events) events. High serum IGF-I was associated with increased risk of CHD events (quintile 5 vs. quintiles 2-4, HR = 1.64, 95% CI 1.28-2.10). In contrast, serum IGF-I was not significantly associated with the risk of cerebrovascular events.
Conclusion: Both low and high serum IGF-I levels are risk markers for CV events in elderly men. The association between high serum IGF-I and CV events is mainly driven by CHD events.
Nothing to Disclose: DC, JS, T, MP, OL, MK, DM, CO
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