Session: FP05-Lipids: Regulation & Mechanism of Disease
Room 133 (Moscone Center)
Poster Board SAT-724
208 woman with PCOS and 120 woman as control were study. NFLD were diagnose on the basis of USG and biochemical markers. Genomic DNA were isolated using standard method. To polymorphisms identification PCR and minisequencing were used. Reaction products were separated on Genetic Analyser ABI 3100. For statistic analysis Hardy-Weinberg Equilibrium was used.
62% woman with PCOS presented NFLD in comparison to 48% in control. Our results showed significantly higher frequency of the A/A genotype of the rs806381 (p<0. 001258) and G/G genotype of the rs10485170 (p<0.000027) in woman with PCOS and NFLD versus PCOS woman without NFLD. These specific correlation was not observed in control group. We observed also significantly higher (p<0.001718) frequency of the A/A genotype of rs1049353 CNR1 polymorphism vs. controls. As well as G/G genotype of the rs806381 CNR1 polymorphism (p<0.000086) vs. controls. The relation between CNR1 polymorphisms to hormonal and metabolic profile will discuss.
Our preliminary results suggest potencial role of the CNR1 polymorphisms in etiology of the NFLD specially in PCOS woman what need further study.
Nothing to Disclose: AJM, LL, JK, AL, KK, MP, FL, MB
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