Session: SAT 248-267-Osteoporosis II
Poster Board SAT-258
Methods: We used data from the fourth Korea National Health and Nutrition Examination Survey 2008–2009. The measurements of anthropometric parameters and bone mass were obtained using dual energy X-ray absorptiometry (DXA) (Discovery-W, Hologic Inc., USA). A total of 7,355 adults (3,345 men and 4,010 women) aged 30 or older had available data. Subjects were divided into three groups and separately analyzed based on sex and menopausal status (men, pre-, and postmenopausal women). Linear regression models were used to analyze relations between insulin and bone mass adjusted for age, household income, education, smoking, alcohol, 25-hydroxy vitamin D, height, weight, fat mass and the markers related to insulin resistance.
Results: After adjustment for confounding factors, there was an inverse association between insulin and total body bone mass [men: β= -0.112, P<0.001; premenopausal women: β= -0.075, P<0.001; postmenopausal women: β= -0.037, P=0.043]. In the stratified analysis, the association between insulin and bone mass was apparent only in individuals with the highest BMI tertile (men: β= -0.152, P<0.001; premenopausal women: β= -0.148, P<0.001; postmenopausal women: β= -0.157, P<0.001).
Conclusion: There was an inverse association between insulin and total body bone mass after adjustment of the confounding factors regardless of sex and menopausal status. However, this association was apparent only in the insulin resistant population. This strongly suggests that any adverse influence of insulin on bone mass is likely to reflect a role of other factors associated with insulin resistance rather than a direct action of insulin itself.
Nothing to Disclose: YJC, JIL, JHY, DJK, YL, YSC
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