Session: MON 142-166-Hypothalamus-Pituitary Development & Biology
Poster Board MON-153
In the Ao-banding group, Ucn-2 and Ucn-3 mRNA expressions were significantly elevated in striatum, hippocampus, thalamus, amygdala and cerebellum compared with control group. Unlike Ucn-2 mRNA expression, Ucn-3 mRNA expression was also elevated in hypothalamus. However, CRF-R2a mRNA expression was downregulated in frontal cortex, striatum, hippocampus, septum, thalamus and hypothalamus. In regard to expression level of TNFa mRNA, no significant difference between Ao-banding and control groups was recognized in any region of the brain. On the other hand, IL-6 mRNA expression of the Ao-banding group was markedly elevated in hippocampus, septum, hypothalamus, amygdala, and pituitary gland similar to patterns of Ucn-2 or Ucn-3 mRNA expression. Conversely, SOCS-3 mRNA expression of the Ao-banding group was markedly decreased in the almost same regions of the brain as IL-6. Protooncogene c-fos (third messenger of IL-6) mRNA level was upregulated in hippocampus, hypothalamus and cerebellum.
Our data indicates that oxidative stress caused by left ventricular heart strain could probably induce chronic inflammation in the rat brain through Ucn-2, Ucn-3 and IL-6, suggesting the involvement of negative feedback of CRF receptors and cytokine signalings. Taken together, these results may lead to the elucidation of stress response mechanism in the central nervous system on the condition of heart failure.
Nothing to Disclose: TM, MI, EW, TU, IM, MY, KT, HI
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