Session: SUN 88-129-Acromegaly & Prolactinoma
Poster Board SUN-107
Methods: Forty-eight acromegalic patients with a mean age of 49.4 ± 10.5 years and a mean disease duration of 6.8 years were enrolled in the study. Beck depression scale (BDS) and Beck anxiety scale (BAS) were used to evaluate psychological status. Berg balance scale (BBS), one-leg stance test (OLST) and 50 meters walking test were used to evaluate balance and falls efficacy scale-international (FES-I) was used to evaluate fear of falling. AcroQoL, a disease specific QoL questionnaire for acromegaly, has 22 items. These items are spread across physical and psychological dimensions. Psychological dimension is divided into appearance and personal relationships sub-dimensions. Spearman correlation anlyses were done among these tests.
Results: ACROQoL total score was negatively correlated with BDS, BAS and FES-I scores and positively correlated with BBS score and OLST. ACROQoL physical score was negatively correlated with BDS, BAS, 50 meters walking test and FES-I scores and positively correlated with BBS score. ACROQoL psychological score was negatively correlated with BDA, BAS and postively correlated with BBS score. ACROQoL appearance score was negatively corraleted with BDS and BAS scores. ACROQoL personal relationships score was negatively correlated with BDS, BAS and FES-I scores and positively correlated with BBS score and OLST. Univariate analysis revealed that FES-I, presence of hypopituitarism and and visual field defects independently affect ACROQoL total score. Regression analysis, in which ACROQoL total score is the dependent variable and BDS, BAS, BBS, OLST, 50 meters walking test and FES-I are the independent variables, showed that only BDS and BAS scores were related with ACROQoL total score.
Discussion: QoL in acromegaly is correlated with psychological status, presence of balance disturbances and fear of falling. This correlation is evident in total ACROQoL score and scores of ACROQoL dimensions and sub-dimensions. However, presence of depression or anxiety was found to independently affect QoL.
Nothing to Disclose: AA, BT, EKK, YU, GCE, YA
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