Session: SUN 678-689-Adipocyte Biology
Poster Board SUN-687
We studied 15 EPaNIC-study neurosurgical patients requiring pre-scheduled repeated follow-up CT-scans and 6 healthy volunteers matched for age, gender and BMI. Repeated abdominal and femoral qCT images were obtained in a standardized manner on median ICU day 2 (IQR 2-3) and day 9 (8-10). Intramuscular, subcutaneous and visceral fat compartments were delineated manually. Muscle and adipose tissue volume and composition were quantified using standard Hounsfield Unit (HU) ranges.
Critical illness evoked substantial loss of femoral muscle volume in one week’s time, irrespective of the nutritional regimen. Early PN reduced the quality of the muscle tissue, as reflected by the attenuation, revealing increased intramuscular water/lipid content. Early PN also increased the volume of adipose tissue islets within the femoral muscle compartment. These changes in skeletal muscle quality correlated with caloric intake. In the abdominal muscle compartments, changes were similar, albeit smaller. Femoral and abdominal subcutaneous adipose tissue compartments were unaffected by disease and nutritional strategy.
In conclusion, early PN did not prevent the pronounced wasting of skeletal muscle observed over the first week of critical illness. Moreover, early PN increased the amount of adipose tissue within the muscle compartments.
Nothing to Disclose: LL, MC, WC, DV, BD, FG, PJW, DM, GV
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