Adenovirus 36 and its Correlation to Obesity and Metabolic Profile in Adolescents and their Family Members

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SAT 697-707-Obesity Pathophysiology
Translational
Saturday, June 15, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SAT-702
Jill Ellen Emerick*1, Noelle Summers Larson2, Candace Suzanne Staubitz Percival3, John Arnold4, Karen Susan Vogt5, David Larson6, Steven Rothwell6, Cara H Olsen7 and Merrily Poth6
1Walter Reed National Military Medical Center, Bethesda, MD, 2WRNMMCB, 3USUHS, Rockville, MD, 4Naval Medical Center San Diego, San Diego, CA, 5Walter Reed National Military Me, Burtonsville, MD, 6USUHS, Bethesda, MD, 7Uniformed Services University of Health Sciences, Bethesda, MD
Although infection of animals with adenovirus 36(AD36) is known to result in obesity, the role of this virus in human obesity remains unclear.  Some, but not all, studies have reported a higher prevalence of AD36-seropositivity in overweight compared to normal weight adults and children.  Seropositive overweight adults have been reported to have better metabolic profiles than those who are seronegative.  To extend these findings to adolescents and to look for evidence of intrafamily transmission of virus we performed a study of children 10 to 18 years of age and their family members.  We used body mass index (BMI) percentile to define them as normal(BMI < 85%) or overweight  (BMI > or equal to the 85%).  AD36 antibody was determined by cell cytotoxic assay and metabolic profile was evaluated using serum lipids, HOMA-IR, and hemoglobin A1c. 

A total of 33 adolescents (median age 14 years) and 21 family member subjects (median age 44.6 years) were studied.  24.2% of adolescents (n=8) were normal weight and 75.8% (n=25) were overweight.  AD36 positivity was present in 28% of overweight adolescents (7/25) compared to 37.5% of normal weight adolescents (3/8).  Of the family member subjects, 23.8% (n=5) were normal weight and 76.2% (n=16) were overweight.  Of overweight family members, 37.5% were AD36 seropositive (6/16) compared to 80% of normal weight family members (4/5). Contrary to findings of previous studies, there was not a statistically significant difference in AD36 seropositivity between normal weight and overweight subjects.  We found that among overweight adolescents, those who were AD36 positive showed a trend toward lower triglycerides than those who were negative for AD36 antibodies.  We also found that 75% of AD36 seropositive adolescents had a similarly affected family member, and among the family member pairs studied, there was a 68% concordance rate for AD36 status.

Prior studies reported 15% of adolescents and 27% of adults were AD36 seropositive compared to 30.3% and 47.6% in our population.  Thus the findings of this study do not support an association between AD36 positivity and obesity, but do suggest that AD36 seropositivity may be higher in military populations and that there is a correlation between AD36 seropositivity and more favorable triglyceride levels in overweight adolescents.  This is also the first study to show that AD36 status is highly concordant among family members.

Nothing to Disclose: JEE, NSL, CSSP, JA, KSV, DL, SR, CHO, MP

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm