Session: SAT 697-707-Obesity Pathophysiology
Poster Board SAT-702
A total of 33 adolescents (median age 14 years) and 21 family member subjects (median age 44.6 years) were studied. 24.2% of adolescents (n=8) were normal weight and 75.8% (n=25) were overweight. AD36 positivity was present in 28% of overweight adolescents (7/25) compared to 37.5% of normal weight adolescents (3/8). Of the family member subjects, 23.8% (n=5) were normal weight and 76.2% (n=16) were overweight. Of overweight family members, 37.5% were AD36 seropositive (6/16) compared to 80% of normal weight family members (4/5). Contrary to findings of previous studies, there was not a statistically significant difference in AD36 seropositivity between normal weight and overweight subjects. We found that among overweight adolescents, those who were AD36 positive showed a trend toward lower triglycerides than those who were negative for AD36 antibodies. We also found that 75% of AD36 seropositive adolescents had a similarly affected family member, and among the family member pairs studied, there was a 68% concordance rate for AD36 status.
Prior studies reported 15% of adolescents and 27% of adults were AD36 seropositive compared to 30.3% and 47.6% in our population. Thus the findings of this study do not support an association between AD36 positivity and obesity, but do suggest that AD36 seropositivity may be higher in military populations and that there is a correlation between AD36 seropositivity and more favorable triglyceride levels in overweight adolescents. This is also the first study to show that AD36 status is highly concordant among family members.
Nothing to Disclose: JEE, NSL, CSSP, JA, KSV, DL, SR, CHO, MP
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