Abstracts - Orals, Featured Poster Presentations, and Posters
MON 142-166-Hypothalamus-Pituitary Development & Biology
Expo Halls ABC (Moscone Center)
Poster Board MON-154
Ageing is associated with increased risk of sleep problems, and reduced sleep duration. Evidence indicates that short sleep duration is associated with an increased risk for cardiovascular events mediated by inflammatory markers. The present study sought to examine the association between total sleep duration and four adipokine hormones and white blood cells in older Chinese. Cross-sectional analysis of sub-set data from the Guangzhou Biobank Cohort Study (GBCS) was performed. Participants (n = 1,533) were aged ≥50 years. Pearson correlation coefficient was used to assess factors that correlate with C-reactive protein (CRP) and multiple linear regression was utilised to assess the relationship between total sleep duration CRP, leptin, adiponectin, plasminogen activator inhibitor-1 (PAI-1), white blood cell, granulocyte, and lymphocyte counts. CRP was higher among females 3.69 (3.63, 3.75) [least squares mean (95% CI)] and was highly correlated with waist circumference (r = 0.175, P < 0.001). CRP was positively associated with fasting glucose (r = 0.080, P < 0.001), LDL-cholesterol (r = - 0.038, P < 0.001), HDL-cholesterol (r = 0.079, P < 0.001), triglyceride levels (r = 0.06, P < 0.001), leptin (r = 0.093, P < 0.001), and adiponectin ( r = -0.104, P < 0.001) after controlling for age, gender and waist circumference. There was no significant association between self-report sleep duration and adipokine levels among older Chinese. There is a high controversy among the studies that previously investigated the association between sleep duration and excessive body weigh among older age groups; our findings on association between adipokine levels and sleep may have been influenced by ageing.
Disclosure: ST: Clinical Researcher, Lilly USA, LLC, Clinical Researcher, Novo Nordisk. Nothing to Disclose: MH, CQJ, KK, TH, GNT
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