Session: FP18-Diabetes: Glycemia & Insulin Sensitivity
Room 304 (Moscone Center)
Poster Board SUN-783
Methods: Overweight non-diabetic subjects (BMI≥25 Kg/m2) without cardiovascular or thyroid disease were recruited for a one-year dietary intervention weight loss program. Study participants received counseling for individualized, calorie-restricted diets and lifestyle modification. During the first 3 months education/support group sessions were offered bi-weekly, and monthly for the remainder of the study. Glucose metabolism, cytokines and anthropometric parameters were recorded at baseline and after 6 and 12 months of dietary intervention. Insulin sensitivity (SI) was calculated with FSIVGTT and Minimal Model.
Results: Twenty-eight subjects (f. 15, m. 13, age 38.6±1.0 year, BMI 33.2±0.9 Kg/m2) completed the study, achieving a weight loss of 9.1± 0.2 kg (P<0.05) and a fat mass loss of 7.7±0.1 kg (P<0.01). At baseline a negative association was observed between SI and fat mass, waist circumference, and hip circumference (P<0.001), but no significant association was observed between SI and IL-2, IL-1b, or IL-10. The intervention resulted in a significant increase in SI (3.0±0.5 baseline, 4.4±0.5 6 months, 4.3±0.6 12 months, P<0.001). A non significant decrease in IL-2, IL-1b, and IL-10 was also observed. Using a mixed model analysis the change in SI was significantly associated with changes in waist-to-hip ratio (WHR) (P<0.02), IL-2 (P<0.05), IL-1b (P<0.03). The changes in fat mass, waist circumference, and IL-1b were independently associated with changes in SI (all P<0.05).
Discussion: Weight loss intervention in non-diabetic overweight and obese subjects resulted in an improvement in the insulin sensitivity and in a moderate, non-significant reduction of the pro-inflammatory cytokines IL-2 and IL-1b. Moreover, the decrease in central adiposity was independently associated with improvement in insulin sensitivity. The data indicate that in this study population although the changes in IL-2, IL-1b, and IL-10 likely explain some of the variability in glucose metabolism observed during controlled weight loss, the majority of the observed changes are secondary to reduction of fat mass.
Nothing to Disclose: TPH, XZ, JDL, SS, ABC, LS, FSC
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