: Enhancement of vitamin D levels by statins

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 257-280-Disorders of Vitamin D Metabolism & Action
Basic/Translational
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-272
Birgit Khandalavala*1, Sreekanth Koneru1, Jenenne Geske1 and Cyrus V Desouza2
1University of Nebraska Medical Center, Omaha, NE, 2Univ of Nebraska Med Center, Omaha, NE
Introduction

Statins reduce cardiovascular risk. A significant part of this risk reduction is attributed to the anti-inflammatory effects of statins.The mechanisms by which these effects are modulated are not fully understood. Vitamin D is inversely associated with cardiovascular risk and has potent anti-inflammatory effects. In this study we hypothesized that statins may exhibit some of their effects by increasing vitamin D levels in patients taking both drugs concomitantly.

 Methods

This is a crossectional study done over a two year period  (2008-2010),in a family practice clinic in a large Midwestern city with a with a latitude of 41degrees in which 355 consecutive patients were enrolled. Demographics included sex, age, height, weight, race ,co-morbid conditions and medications were collected. Blood samples were collected for Vitamin D25  levels, lipid level and hsCRP .

Results

The mean age of patients was 50.6 years (SD=14.1) and the mean BMI was 29.79 (SD=6.7). Of patients for whom race was identified, 85% were White. 72% of the sample was female. 96 patients (27% of the sample) were on statins for hyperlipidemia ; 259(73%) were not on a statin . The mean dose of Vitamin D supplementation for patients on statins was 2300 units versus 2700 units for those patients not on statins, (P=0.44). The mean vitamin D level of the entire sample was 29.44 ng/ml (SD=13.5). Vitamin D levels of over 30 were considered replete. A total of 197 (56%) of the entire sample was not replete, and 158 (44%) of the 355 were.  Of the 259 patients who were not on a statin, 105 (40.5%) were replete; however 53 of the 96 patients taking a statin (55.2%) concomitant were found to be replete in vitamin D. Results of a ChiSquare analysis revealed that patients who were taking statins were significantly more likely to have vitamin D levels at or above 30ng/ml (X2=5.5, p=0.02) than patients not on a statin.

Discussion

Our study shows that treatment of statins was associated with a higher vitamin D level with the same level of supplementation. This suggests that one of the mechanisms by which statins exert their anti-inflammatory/cardioprotective effects may be due to an increase in the vitamin D level.  It is possible that people who take statins are more likely to take vitamin D. It is possible that absorption, storage or metabolism of vitamin D may also be affected by statins. The exact mechanism of this effect is not known and further studies need to be done to clarify this association.

Disclosure: CVD: Consultant, Novo Nordisk, Consultant, Takeda. Nothing to Disclose: BK, SK, JG

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm