Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SAT 697-707-Obesity Pathophysiology
Saturday, June 15, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SAT-703
Mehmet Boyraz1, Ediz Yesilkaya*2, Fatih Ezgu3, Aysun Bideci4, Orhun Çamurdan5, Abdulbaki Karaoglu1, Erkan Sari1, Haldun Dogan6 and Peyami Cinaz4
1GATA, 2Gülhane Military Medical Academy, ANKARA, Turkey, 3GAZI, 4Gazi Üniversitesi Tip fakültesi Pediyatri ABD, Ankara, Turkey, 5Gazi Üniversitesi Tip Fakültesi Cocuk Sagligi ABD, Ankara, Turkey, 6INTERGEN
Aims: SOCS3 gene encoding the SOCS-3 protein was previously shown to mediate cytokine signaling. Although polymorphisms in SOCS3 gene was reported to be related to obesity, metabolic syndrome and type 2 diabetes in various adult studies, there is a lack of data in children. In this study, we examined eight polymorphisms in the SOCS3 gene in 148 obese Turkish children with and without metabolic syndrome and compared the results with that of 63 age and sex matched controls. Results: The frequency of rs2280148 polymorphism was significantly higher in obese children with metabolic syndrome than that of the control group, whereas the frequency of rs8064821 polymorphism was significantly higher in obese children with metabolic syndrome than that of  obese children without metabolic syndrome. Conclusions: The significant association of certain SOCS3 gene polymorphisms with obesity parameters in both metabolic syndrome and metabolic syndrome related insulin resistance, hypertension, and fatty liver suggests that polymorphisms in this gene may play a role in the pathogenesis of metabolic syndrome and also that they can be potentially used as a marker for attenuated or agressive disease.

Gylvin T, Nolsoe R, Hansen T, Nielsen EM, Bergholdt R, Karlsen AE, Billestrup N,Borch-Johnsen K, Pedersen O, Mandrup-Poulsen T, Nerup J, Pociot F. Mutation analysis of suppressor of cytokine signalling3, a candidate gene in Type 1 diabetes and insulin sensitivity. Diabetologia 2004;47:1273-7. Holter K, Wermter AK, Scherag A, Siegfried W, Goldschmidt H, Hebebrand J, Hinney A. Analysis of sequence variations in the suppressor of cytokine signaling (SOCS)-3 gene inextremely obese children and adolescents. BMC Med Genet 2007;8:21. Howard JK, Flier JS. Attenuation of leptin and insulin signaling by SOCS proteins. Trends Endocrinol Metab 2006;17:365-71. Jamshidi Y, Snieder H, Wang X, Spector TD, Carter ND, O'Dell SD. Common polymorphisms in SOCS3 are not associated with body weight, insulin sensitivity or lipid profile in normal female twins. Diabetologia 2006;49:306-10. Ueki K, Kondo T, Tseng YH, Kahn CR. Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse. Proc Natl Acad Sci USA 2004;101:10422-7. Ueki K, Kadowaki T, Kahn CR. Role of suppressors of cytokine signaling SOCS-1 and SOCS3 in hepatic steatosis and the metabolic syndrome. Hepatol Res 2005;33:185-92.

Nothing to Disclose: MB, EY, FE, AB, O, AK, ES, HD, PC

*Please take note of The Endocrine Society's News Embargo Policy at