SOCS3 GENE POLYMORPHISMS IN CHILDHOOD OBESITY: IS THE CYTOKINE SYSTEM IN OPERATION?

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SAT 697-707-Obesity Pathophysiology
Translational
Saturday, June 15, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SAT-703
Mehmet Boyraz1, Ediz Yesilkaya*2, Fatih Ezgu3, Aysun Bideci4, Orhun Çamurdan5, Abdulbaki Karaoglu1, Erkan Sari1, Haldun Dogan6 and Peyami Cinaz4
1GATA, 2Gülhane Military Medical Academy, ANKARA, Turkey, 3GAZI, 4Gazi Üniversitesi Tip fakültesi Pediyatri ABD, Ankara, Turkey, 5Gazi Üniversitesi Tip Fakültesi Cocuk Sagligi ABD, Ankara, Turkey, 6INTERGEN
Aims: SOCS3 gene encoding the SOCS-3 protein was previously shown to mediate cytokine signaling. Although polymorphisms in SOCS3 gene was reported to be related to obesity, metabolic syndrome and type 2 diabetes in various adult studies, there is a lack of data in children. In this study, we examined eight polymorphisms in the SOCS3 gene in 148 obese Turkish children with and without metabolic syndrome and compared the results with that of 63 age and sex matched controls. Results: The frequency of rs2280148 polymorphism was significantly higher in obese children with metabolic syndrome than that of the control group, whereas the frequency of rs8064821 polymorphism was significantly higher in obese children with metabolic syndrome than that of  obese children without metabolic syndrome. Conclusions: The significant association of certain SOCS3 gene polymorphisms with obesity parameters in both metabolic syndrome and metabolic syndrome related insulin resistance, hypertension, and fatty liver suggests that polymorphisms in this gene may play a role in the pathogenesis of metabolic syndrome and also that they can be potentially used as a marker for attenuated or agressive disease.

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Nothing to Disclose: MB, EY, FE, AB, O, AK, ES, HD, PC

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