INCREASED MORTALITY IN GERIATRIC OBESE MICE IS IMPROVED BY LIFESTYLE THERAPY

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SAT 708-722-Obesity: Response to Interventions
Basic
Saturday, June 15, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SAT-714
Lina E Aguirre*1, Xavier A De Leon2, Dennis Tan Villareal3 and Reina Condevillamar Villareal3
1Biomedical Research Institute of New Mexico (BRINM), Albuquerque, NM, 2Biomedical Research Institute of New Mexico, Albuquerque, NM, 3New Mexico VA Health Care System, Albuquerque, NM
Background and objective: To date, the care of elderly obese patients remains controversial as geriatricians are reluctant to advise weight loss as part of standard of care for these patients. Excess weight is deemed to be beneficial and weight loss harmful in this subset of patients. The perception is that excess weight is protective against catabolism during severe illnesses in the elderly. However, little or no information is available on the effect of intentional weight loss from lifestyle therapy on survival in the elderly obese patients. The objective in this study is to determine if lifestyle intervention affects in survival in elderly obese male mice.

Methods:  To create a model of obese old mice, 40 middle-aged male C57BL/6 mice (15 to 16 months) were fed either a high fat diet (60% fat) (n=32) for 12 weeks or standard mouse chow (n=8). At the end of 12 weeks, mice fed a high fat diet were subsequently assigned to: 1) continue high fat diet (HFD, n=8), 2) caloric restriction to induced weight loss of 15 to 25% (Diet, n=8), 3) endurance exercise (EX, n=8) and 4) diet and exercise (Diet+EX, n=8). The lean control (CTRL) mice were continued on standard mouse chow. Half of the mice were assigned to the above interventions for 6 weeks (mice purchased at 16 months) while the other half were assigned to 12 weeks of intervention (mice purchased at 15 months).

Results:Mice assigned to high fat diet were on the average 140 to 160% heavier than the lean control mice. Weight loss of 17 to 22% was achieved among mice assigned to diet and diet+EX for 6 weeks and 21 to 25% among mice assigned to diet and diet+EX for 12 weeks.  There was a 30% overall attrition rate regardless of the length of intervention. The best survival were observed among mice assigned to lean control or diet (75 to 100%) while the worst survival was for mice assigned to high fat diet (25 to 50%).

Conclusion: To our knowledge our group has created the first animal model of combined aging and obesity. Lifestyle intervention which included weight loss improved survival in these male obese old mice.  Our results in animals need to be confirmed in human studies to determine if intentional weight loss in the obese, elderly human patients may indeed be beneficial and increase survival.

Nothing to Disclose: LEA, XAD, DTV, RCV

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm

Sources of Research Support: Veterans Affairs Project 002 ACORP 10-RV-34