Session: SAT 708-722-Obesity: Response to Interventions
Poster Board SAT-714
Methods: To create a model of obese old mice, 40 middle-aged male C57BL/6 mice (15 to 16 months) were fed either a high fat diet (60% fat) (n=32) for 12 weeks or standard mouse chow (n=8). At the end of 12 weeks, mice fed a high fat diet were subsequently assigned to: 1) continue high fat diet (HFD, n=8), 2) caloric restriction to induced weight loss of 15 to 25% (Diet, n=8), 3) endurance exercise (EX, n=8) and 4) diet and exercise (Diet+EX, n=8). The lean control (CTRL) mice were continued on standard mouse chow. Half of the mice were assigned to the above interventions for 6 weeks (mice purchased at 16 months) while the other half were assigned to 12 weeks of intervention (mice purchased at 15 months).
Results:Mice assigned to high fat diet were on the average 140 to 160% heavier than the lean control mice. Weight loss of 17 to 22% was achieved among mice assigned to diet and diet+EX for 6 weeks and 21 to 25% among mice assigned to diet and diet+EX for 12 weeks. There was a 30% overall attrition rate regardless of the length of intervention. The best survival were observed among mice assigned to lean control or diet (75 to 100%) while the worst survival was for mice assigned to high fat diet (25 to 50%).
Conclusion: To our knowledge our group has created the first animal model of combined aging and obesity. Lifestyle intervention which included weight loss improved survival in these male obese old mice. Our results in animals need to be confirmed in human studies to determine if intentional weight loss in the obese, elderly human patients may indeed be beneficial and increase survival.
Nothing to Disclose: LEA, XAD, DTV, RCV
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