SELENIUM, ZINC, COPPER LEVELS IN CHILDHOOD TYPE I DIABETES MELLITUS

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 839-872-Diabetes & Obesity Management
Clinical
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-848
Salim Ozenc1, Sirzat Yesilkaya*2, Ediz Yesilkaya3, Necati Balamtekin1, Semra Cetinkaya4, Mehmet Saldir1, Nadir Korkmazer1, Galip Erdem2, Emre Tascilar1 and Mehmet Baysallar1
1GATA, 2gata, 3Gülhane Military Medical Academy, ANKARA, Turkey, 4Sami Ulus Childrens Hosp, Ankara, Turkey
Background:In recent years, the oxidative stress-induced free radicals have been implicated in the pathogenesis of type 1 diabetes mellitus (DM). It has been also reported that elements like selenium (Se), zinc (Zn) and copper (Cu) involved in lipid peroxidation might take part in this disease. The aim of the present study was to evaluate the antioxidant status and micronutrient levels in children with type 1 DM.

Methods: The study included 35 type 1 DM children (16 girls and 19 boys) with a mean age of 13.87±4.55 years and mean disease duration of 3.66±2.81 years; and 26 age-matched healthy children (11 girls, 15 boys) with a mean age 12.85±3.39 years.

Results: Mean Se and Zn levels of children with DM were significantly lower than those of controls’. HbA1c levels were found to be inversely correlated with Se and Zn levels. No statistically significant difference was found between serum Cu contents of DM patients and controls. GSH-Px levels were lower in DM patients when compared with those of controls’, and there was a negative correlation between HbA1c and GSH-Px levels.

Conclusions: We believe that these low levels stem from the increased oxidative stress. Those elements could be closely monitored during the course of type 1 DM and their supplementation may be given in certain patients.

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Nothing to Disclose: SO, SY, EY, NB, SC, MS, NK, GE, ET, MB

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm