Abstracts - Orals, Featured Poster Presentations, and Posters
SUN 839-872-Diabetes & Obesity Management
Expo Halls ABC (Moscone Center)
Poster Board SUN-848
Background:In recent years, the oxidative stress-induced free radicals have been implicated in the pathogenesis of type 1 diabetes mellitus (DM). It has been also reported that elements like selenium (Se), zinc (Zn) and copper (Cu) involved in lipid peroxidation might take part in this disease. The aim of the present study was to evaluate the antioxidant status and micronutrient levels in children with type 1 DM.
Methods: The study included 35 type 1 DM children (16 girls and 19 boys) with a mean age of 13.87±4.55 years and mean disease duration of 3.66±2.81 years; and 26 age-matched healthy children (11 girls, 15 boys) with a mean age 12.85±3.39 years.
Results: Mean Se and Zn levels of children with DM were significantly lower than those of controls’. HbA1c levels were found to be inversely correlated with Se and Zn levels. No statistically significant difference was found between serum Cu contents of DM patients and controls. GSH-Px levels were lower in DM patients when compared with those of controls’, and there was a negative correlation between HbA1c and GSH-Px levels.
Conclusions: We believe that these low levels stem from the increased oxidative stress. Those elements could be closely monitored during the course of type 1 DM and their supplementation may be given in certain patients.
Maritim AC, Sanders RA, Watkins JB. Diabetes, oxidative stress, and antioxidants: a review. J. Biochem. Mol. Toxicol. 2003; 17: 24-38.Wolf SP. Diabetes mellitus and free radicals. Free radicals, transition metals and oxidative stress in the etiology of diabetes mellitus and complications. Br. Med. Bull. 1993; 49: 642-52.Ruiz C, Alegria A, Barbera R, Farre R, lagarda J. Selenium, zinc and copper in plasma of patients with type 1 diabetes mellitus in different metabolic states. J. Trace Elem. Med. Biol. 1998; 12: 91-5.Isbir T, Tamer L, taylor A, Isbir M. Zinc, copper and magnesium status in insulin-dependent diabetes. Diabetes Res. 1994; 26: 41-5.Bideci A, Camurdan MO, Cinaz P, Dursun H, Demirel F. Serum zinc, insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels in children with type 1 diabetes mellitus. J. Pediatr. Endocrinol. Metab. 2005; 18: 1007-11.Tuvemo T, Ewald U, Kobbah M, Proos LA. Serum magnesium and protein concentrations during the first five years of insulin-dependent diabetes in children. Acta. Paediatr. Suppl. 1997; 418: 7-10. Kruse-Jarres JD, Rukgauer M. Trace elements in diabetes mellitus. Peculiarities and clinical validity of determinations in blood cells. J. Trace Elem. Med. Biol. 2000; 14: 21-7.Bach K, Haas H, Mathieu A. Concentrations of selenium in nutrition and blood serum of diabetic children and adolescents. Padiat. Padol. 1991; 26: 83-5
Nothing to Disclose: SO, SY, EY, NB, SC, MS, NK, GE, ET, MB
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