Does Winter Time Vitamin D3 Deficiency Result in Parathyroid Hormone and Osteocalcin Deviation in Healthy 1826 Year Old Males?

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 238-262-Vitamin D Action, Deficiency & Disorders
Bench to Bedside
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-257
Ieva Gailyte, Lina Lasaite, Rasa Verkauskiene, Gintautas Kazanavicius and Romualdas Tomas Preiksa*
Lithuanian University of Health Sciences, Kaunas, Lithuania

The aim of the study was to evaluate vitamin D3 levels in young healthy Lithuanian male group in winter and to find out possible associations of vitamin D3 concentration to parathyroid hormone (PTH) and osteocalcin.

Subjects and Methods. A total of 262 healthy Lithuanian male military conscripts (age range 18–26 years) were tested for vitamin D3, PTH and osteocalcin concentration and 155 (59.2%) of them we rechecked one year later. Vitamin D3 (25(OH)D3), PTH and N-MID osteocalcin were assayed using electrochemoluminescence immunoassay (ECLIA) method.

Results. Primary vitamin D3 deficiency (<20 ng/ml) was detected in 95.0% and 96.7% when rechecked. The mean concentration of vitamin D3 was 12.5±4.5 ng/ml and 10.4±4.9 ng/ml one year later. Nevertheless, PTH (2.54±1.23 pmol/l) and osteocalcin (38.9±11.9 ng/ml) concentration when checked and rechecked (2.70±1.10 pmol/l and 40.4±12.8 ng/ml, respectively) were in normal ranges. A weak Spearman rank order correlation (r=-0.2; p=0.0273) between vitamin D3 and PTH was detected when rechecked only. In one year period, vitamin D3 deficiency became more severe in 79 (55.6%) of studied males, remained the same in 46 (32.4%) and relieved in 17 (12.2%). In case of increase of vitamin D3 deficiency trough a period of one year, osteocalcin concentration increased in average by 4.40±10.4 ng/ml, while it decreased by 1.8±9.0 ng/ml if vitamin D3 deficiency relieved (F=3.32; p=0.039). The cases of stable vitamin D3 concentration also showed stability in osteocalcin concentrations.

Conclusion. The majority of the young healthy males participating in the study was detected to have vitamin D3 deficiency in winter. Low vitamin D3 concentrations were not associated with impaired PTH and osteocalcin concentrations of the tested men. Nevertheless we speculate, that dynamic vitamin D3 deficiency aggravation in young men could result in osteocalcin concentration significant deviation.

Nothing to Disclose: IG, LL, RV, GK, RTP

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