Session: MON 292-305-MEN1, MEN2 & Pheochromocytomas
Poster Board MON-301
The aims of this study were to: (1) audit imaging modalities employed in VHL in our institution, (2) calculate the Cumulative Effective Dose (CED) of diagnostic radiation; (3) determine factors associated with an increased risk to a high CED.
All patients with von Hippel-Lindau attending a single tertiary referral centre in the South West of Ireland were included. CED was calculated from a retrospective audit of all available imaging in the cohort up to September 2011; additionally patients were contacted by mail to quantify external imaging. High exposure was defined as CED > 75 mSv. 18 patients (9 male, 9 female) were included in this analysis. Mean age of the cohort was 36.8 years. A total of 617 imaging studies were performed; Computed Tomography (CT) accounted for 45 % of all studies and 86% of the diagnostic radiation. 12 Patients (66%) showed at least one imaging manifestation of malignancy. Median CED was 96 mSv (CI 55.72-216.76mSv). 9 (50%) patients had a High CED. Abdominal CT significantly contributed to the CED (49%) and total CT burden (38 %). Factors associated with a high CED included; previous diagnosis of a neoplasm and increasing age (p values .001 and .002).
VHL requires lifelong radiological surveillance and predisposes this cohort of patients to the risk of radiation induced cancer and toxicity. In this study, CT was the favoured imaging modality. Taking into account the cumulative risk attributable to genetic predisposition, high CED, regular imaging, we conclude that alternative imaging modalities such as MRI should be considered in this cohort for screening and follow
Nothing to Disclose: SO, RC, SO, AAT, MM, DJO, PM
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