Decreased TWEAK Level is Related with Insulin Resistance in Patients with Polycystic Ovary Syndrome

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 498-523-Female Reproductive Endocrinology & Case Reports
Clinical
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-509
Aydogan Aydogdu*1, Ilker Tasci1, Serkan Tapan1, Cem Haymana1, Alper Sonmez1, Sebnem Aydogdu2, Erol Bolu1 and Omer Azal1
1Gulhane School of Medicine, Ankara, Turkey, 2Mevki Military Hospital, Ankara, Turkey
BACKGROUND: Polycystic ovary syndrome (PCOS) is characterized by insulin resistance (IR). Chronic low-grade inflammation has been anticipated to play a major role in the pathogenesis of both IR and atherosclerosis. Tumor necrosis factor like weak inducer of apoptosis (TWEAK) has recently been proposed to be a new biomarker for subclinical inflammation and atherosclerosis. In the present study, serum TWEAK levels and its relationship with IR were determined in patients with PCOS. 

METHODS: Forty patients with PCOS and forty age and body mass index (BMI) matched healthy controls were enrolled in the study. TWEAK and High sensitivity C reactive protein (hs-CRP levels were determined by Enzyme immunoassay (EIA). IR was calculated by the Homeostasis model assessment of IR (HOMA-IR) formula.

RESULTS: Plasma triglyceride, LH/FSH ratio, testosterone, insulin, hs-CRP levels and HOMA-IR score were significantly higher (p=0.0001, p=0.0001, p=0.0001, p=0.003, p=0.0001, respectively) where as HDL-C and TWEAK levels were significantly lower (p=0.02, p=0.0001, respectively) in women with PCOS compared to healthy controls (Table 1). HOMA-IR score correlated positively with BMI, triglyceride, total testosterone, hs-CRP, waist- to-hip ratio (WHR) and negatively with high density Cholesterol (HDL-C) and TWEAK level (p<0.05, for all). After adjustment for age and BMI, TWEAK, total testosterone levels and WHR remained as the independent predictors of HOMA-IR score in logistic regression analysis (p<0.05, for all) (Table 2).

Nothing to Disclose: AA, IT, ST, CH, AS, SA, EB, OA

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm