Does the treatment of vitamin D deficiency optimize strontium ranelate absorption?

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 238-262-Vitamin D Action, Deficiency & Disorders
Bench to Bedside
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-255
Tatiane Vilaca*1, Marília Brasilio Rodrigues Camargo2, Olguita Ferreira3 and Marise Lazaretti-Castro4
1Universidade Federal de Sao Paulo UNIFESP, Sao Paulo, Brazil, 2Universidade Federal de Sao Paulo UNIFESP, 3CETEC Centro Tecnológico de Minas Gerais, 4UNIFESP, Sao Paulo SP, Brazil
Background and Purpose: Strontium ranelate is a drug used to treat osteoporosis. Calcium and strontium have common features and are absorbed by the same pathways.  Vitamin D is important to calcium absorption. The aim of the present study was to determine whether vitamin D status is a determinant of strontium ranelate absorption.

Methods: Twenty-five patients with vitamin D deficiency (25(OH)D < 50 nmol/L) and 25 with vitamin D sufficiency (25 (OH)D > 75 nmol/L) were submitted to an oral strontium overload test. The deficient patients were treated until reaching adequate vitamin D levels (25(OH)D > 75 nmol/L) and the test was repeated. Strontium absorption was evaluated as the fraction of the absorbed dose and the area under the curve.

Results: No differences were found in the parameters used to evaluate Sr absorption between the vitamin D deficient and sufficient groups. Moreover, no difference in Sr absorption was found in the deficient group following treatment.  Changing vitamin D status from deficient to sufficient resulted in a significant increase in 1,25(OH)2D and a reduction in PTH.

Conclusion: Taking into account the benefits of correcting vitamin D status in osteoporotic patients, we strongly recommend the treatment of vitamin D deficiency. However, the data demonstrate that such treatment does not enhance strontium ranelate absorption.

Papworth DG, Patrick G (1970) The kinetics of influx of calcium and strontium into rat intestine in vitro.J Physiol 210:999-1020. Khan AH, Rohra DK, Saghir SA, Udani SK, Wood RJ, Jabbar A.(2012) No change in calcium absorption in adult Pakistani population before and after vitamin D administration using strontium as surrogate. Osteoporos Int. 2012 May 10.DOI: 22572965 Need AG, Nordin BE.(2008) Misconceptions - vitamin D insufficiency causes malabsorption of calcium. Bone 42(6):1021-4.

Nothing to Disclose: TV, MBRC, OF, ML

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Sources of Research Support: Strontium ranelate was kindly provided by Servier.An unconditional grant was received from Servier for part of the 25-hydroxyvitamin D and Strontium measurements.