Session: MON 238-262-Vitamin D Action, Deficiency & Disorders
Bench to Bedside
Poster Board MON-255
Methods: Twenty-five patients with vitamin D deficiency (25(OH)D < 50 nmol/L) and 25 with vitamin D sufficiency (25 (OH)D > 75 nmol/L) were submitted to an oral strontium overload test. The deficient patients were treated until reaching adequate vitamin D levels (25(OH)D > 75 nmol/L) and the test was repeated. Strontium absorption was evaluated as the fraction of the absorbed dose and the area under the curve.
Results: No differences were found in the parameters used to evaluate Sr absorption between the vitamin D deficient and sufficient groups. Moreover, no difference in Sr absorption was found in the deficient group following treatment. Changing vitamin D status from deficient to sufficient resulted in a significant increase in 1,25(OH)2D and a reduction in PTH.
Conclusion: Taking into account the benefits of correcting vitamin D status in osteoporotic patients, we strongly recommend the treatment of vitamin D deficiency. However, the data demonstrate that such treatment does not enhance strontium ranelate absorption.
Nothing to Disclose: TV, MBRC, OF, ML
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