Session: MON 471-496-Thyroid Neoplasia & Case Reports
Poster Board MON-491
Patients and Methods: We enrolled 205 patients admitted to Tottori University Hospital for complaining of thyroid nodules or thyroid dysfunction from November 2011 to June 2012. C-US pattern and VTTQ were evaluated by 3 technicians and 2 doctors not informed of medical records and laboratory findings. AITD was defined by at least 2 of the following 3 conventional US manifestations generated by 14 MHz transducer.
- diffuse low echogenity
- increased blood flow signal
- diffuse goiter
All patients were evaluated in supine position with dorsal flexion of the head. VTTQ of each lobe was measured in line with the longest diameter. VTTQ was calculated 3 times on each position and average value was enrolled for the analysis. The values were expressed as meters/second (m/s). Odds ratio (OR) was adjusted for sex, age, and body mass index.
Results: The C-US manifestation of AITD was observed in 102 patients. The positivity of autoantibodies, hypothyroidism, and hyperthyroidism was significantly higher in AITD (p<0.01). The average VTTQ was significantly higher in patients with AITD than those without AITD (2.21 m/s vs. 2.03 m/s, p<0.01). The value of VTTQ (OR 2.27, 95% CI 1.13-4.60, p=0.02) was associated with the C-US manifestation of AITD. However, the OR was smaller than that of TgAb positive (7.03, 2.88-17.13, p<0.01) and TPOAb positive (34.07, 7.35-157.83, p<0.01). Cytologically benign TNs were observed in 56 patients (18 with AITD and 38 without AITD) by C-US. The average value of TNs coexistent with AITD was similar to that without AITD (2.17m/s vs. 2.03 m/s, p=0.59).
Conclusion: The value of VTTQ is associated with the presence of AITD, though the diagnostic power is not superior to thyroid autoantibodies. Our data indicate that the value of VTTQ is feasible for evaluating the stiffness of TNs, and not influenced by the surroundings like AITD.
Nothing to Disclose: SI, KM, YA, MM, MF, TO, HO, AY, MK, SIT, KY
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