Session: MON 776-795-Cardiometabolic Risk & Vascular Biology
Poster Board MON-783
Materials and methods: Two hundred forty patients with T2DM (mean age: 66 years, mean duration of diabetes 13,7 ± 8,9 years) were included in the study. Circulating levels of OC, PTH 1-84, Beta-crosslaps, Nt-proBNP and hsTnT were determined with the Cobas® e411 analyzer (Roche Diagnostics).
Results: OC levels were significantly lower in T2DM patients (mean: 12.9 ng/mL) than in healthy individuals (25 ng/mL). Mean circulating levels were 175 mg/dL for fasting glucose (range: 95 – 390), 7.7% for HbA1c (5.3 – 11.9), 0.190 ng/mL for Beta-crosslaps (0.044 – 0.632), 24.8 pg/mL for PTH 1-84 (5.6 – 83.5), 12.9 pg/mL for hsTnT (3.6 – 79.2) and 151 pg/mL for Nt-proBNP (5 – 832). In multiple regression analysis adjusted for age, duration of diabetes, body mass index and serum creatinin OC levels were negatively correlated to HbA1c (r = -0.198, P = 0·0143) and positively correlated to PTH 1-84 (r = 0.595, P = 0.02), Beta-crosslaps (r = -0.781, P < 0.001) and Nt-proBNP (r = 0.310, P = 0.024). OC levels were not significantly related to hsTnT levels.
Conclusions: Our results suggest an independent association of OC levels with markers of bone turnover in patients with T2DM and with Nt-proBNP, a biomarker related to cardiovascular risk.
Nothing to Disclose: DG, AB, TL, MH
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