Increased Visceral Adiposity Index in Paitents with Polycystic Ovary Syndrome; Relationship between Inflammation, Insulin Resistance and Hyperandrogenity

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 498-523-Female Reproductive Endocrinology & Case Reports
Clinical
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-513
Sebnem Aydogdu*1, Aydogan Aydogdu2, Serkan Tapan2 and Omer Azal2
1Mevki Military Hospital, Ankara, Turkey, 2Gulhane School of Medicine, Ankara, Turkey
OBJECTIVE: Polycystic ovary syndrome (PCOS) is characterized by insulin resistance, hyperandrogenism and subclinical inflammation. Visceral obesity is associated with
 proinflammatory activity, 
deterioration of insulin sensitivity, increased risk of developing diabetes, hypertension, atherosclerosis, and higher mortality rate. We searched if the patients with PCOS have increased visceral adiposity index (VAI) and along with its relation to the measures of inflammation, insulin sensitivity and hyperandrogenism.

METHODS: Thirty-nine patients with PCOS and fifty-two age and body mass index (BMI) matched healthy controls were enrolled in the study. VAI was calculated by the formula-[Waist Circumference / (36.58+(1.88XBMI))] x (Triglyceride/0.81) x (1.52/HDL-Cholesterole). High sensitivity C reactive protein (hs-CRP) level was determined by Enzyme immunoassay (EIA). IR was calculated by the Homeostasis model assessment of IR (HOMA-IR) formula.

RESULTS: Plasma triglyceride, LH/FSH ratio, testosterone, insulin, hs-CRP levels, HOMA-IR score and VAI were significantly higher (p=0.0001, p=0.002, p=0.0001, p=0.0001, p=0.003, p=0.0001, p=0.0001, respectively) where as HDL-C level was significantly lower (p=0.02) in women with PCOS compared to healthy controls (Table 1). VAI correlated positively with BMI (r=0.482, p=0.0001), hs-CRP (r=0.273, p=0.042), waist-to-hip ratio (r=0.394, p=0.001) and HOMA-IR (r=0.514, r=0.0001). Testosterone (r=0.127, p=0.305) and LH/FSH (r=0.209, p=0.084) did not significantly correlated with VAI. (Table 2).

CONCLUSION: VAI is increased in patients with PCOS in concordance with insulin resistance and inflammation. We found no relationship between hyperandrogenism and VAI in PCOS patients.

Nothing to Disclose: SA, AA, ST, OA

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm