Session: SUN 498-523-Female Reproductive Endocrinology & Case Reports
Poster Board SUN-513
METHODS: Thirty-nine patients with PCOS and fifty-two age and body mass index (BMI) matched healthy controls were enrolled in the study. VAI was calculated by the formula-[Waist Circumference / (36.58+(1.88XBMI))] x (Triglyceride/0.81) x (1.52/HDL-Cholesterole). High sensitivity C reactive protein (hs-CRP) level was determined by Enzyme immunoassay (EIA). IR was calculated by the Homeostasis model assessment of IR (HOMA-IR) formula.
RESULTS: Plasma triglyceride, LH/FSH ratio, testosterone, insulin, hs-CRP levels, HOMA-IR score and VAI were significantly higher (p=0.0001, p=0.002, p=0.0001, p=0.0001, p=0.003, p=0.0001, p=0.0001, respectively) where as HDL-C level was significantly lower (p=0.02) in women with PCOS compared to healthy controls (Table 1). VAI correlated positively with BMI (r=0.482, p=0.0001), hs-CRP (r=0.273, p=0.042), waist-to-hip ratio (r=0.394, p=0.001) and HOMA-IR (r=0.514, r=0.0001). Testosterone (r=0.127, p=0.305) and LH/FSH (r=0.209, p=0.084) did not significantly correlated with VAI. (Table 2).
CONCLUSION: VAI is increased in patients with PCOS in concordance with insulin resistance and inflammation. We found no relationship between hyperandrogenism and VAI in PCOS patients.
Nothing to Disclose: SA, AA, ST, OA
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