PLATELET AGGREGATION AND SECRETION TESTS IN HASHIMOTO'S THYROIDITIS

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 437-470-Non-neoplastic Thyroid Disorders
Basic/Clinical
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-445
Suheyla Gorar*1, Bulent Alioglu2, Handan Bekdemir2, Fatma Dilek Dellal3, Beylan Saglam4 and Yalcin Aral5
1Antalya Training and Research Hospital, Antalya, Turkey, 2Ankara Training and Research Hospital, Turkey, 3Agri Government Hospital, Agri, Turkey, 4Ankara Training and Training Hospital, Turkey, 5Ankara Training and Research Hospital, Ankara, Turkey
Introduction: Various changes in the hemostatic system have been described in patients with thyroid disease. The role of platelets in hemostasis are important. Hashimoto’s Thyroiditis (HT) is a frequently chronic autoimmune disease in thyroid gland. The aim of this study is to compare the platelet aggregation and secretion tests in HT and healthy controls.

Method: A total of 75 women were evaluated. Forty-six patients with HT (21 subjects of HT TSH≥5 mIU/mL, 25 subjects of HT TSH<5 mIU/mL) and 29 healthy controls were enrolled. Age, TSH, free T3, free T4, anti M, anti Tg, hemoglobin, platelet count, prothrombin time (pT), partial thromboplastin time (pTT), platelet function tests were studied all of cases. Data analysis was performed SPSS. Firstly, HT patients were compared with the control group, then a total of 46 women with HT were divided into two groups according to TSH as TSH<5 mIU/mL and TSH≥5 mIU/mL.

Results: No difference were found between the groups with respect to hemoglobin, platelet count, pT, pTT. Statistically significant difference was not found in terms of platelet aggregation induced by arachidonic acid, epinephrin, collagen, thrombin, ristocetine and secretion tests induced by ADP, arachidonic acid, epinephrine, collagen, thrombin. But, ADP platelet aggregation test were significantly increase in healthy controls compared to all HT cases and between groups (TSH<5 mIU/mL and TSH≥5 mIU/mL in HT), respectively p<0.012 and p< 0.030. Similarly, ristocetine platelet secretion test higher in healthy controls than all HT cases and between groups (TSH<5 mIU/mL and TSH≥5 mIU/mL in HT), respectively p<0.006 and p< 0.018.

Conclusion: Our knowledge on the effects of thyroid diysfunction on platelet aggregation and secretion tests is sufficient. Therefore, our study may be significant. Our study findings show that patient with HT reduce the platelet aggregation and decrease the secretion property of platelets. As a result of this, we consider that hypothyroidism and autoimmunity may associated with a hypoaggregability and bleeding tendency. Additionally, further studies are needed to investigate the relationship between thyroid dysfunction and platelet function.

Nothing to Disclose: SG, BA, HB, FDD, BS, YA

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