Session: SUN 130-162-Neuroendocrinology
Poster Board SUN-139
Objectives: To describe the hyponatremia frequency in patients with SL and to analyze differences in lesion size, age and adrenal and thyroid status.
Patients and Methods: We retrospectively reviewed the clinical records of 108 patients with sellar lesions who consulted in our endocrinology unit from January 2011 to December 2012. Fifty-eight patients with SL whose natremia had been measured at the time of diagnosis were included. Age, gender, lesion size, adrenal and thyroid status were evaluated.
We divided all patients in two groups by age: 1) 16 to 65 and 2) more than 65-years old; and in three different groups by size: a) macroadenoma, b) microadenoma and c) empty sella. Hyponatremia was defined by a plasma sodium level less than 135 mEq/l, adrenal insufficiency by a morning plasmatic cortisol less than 10 ug/dl and hypothyroidism by a Free-T4 serum level less than 0,93ug/dl.
Chi-square tests were used to compare the distribution difference of categorical variables. A binary logistic regression analyses was performed to evaluate predictive variables of hyponatremia.
Results: Median age was 47 years (range 16-89), 70% were female, 16 of 58 patients had empty sella syndrome (27,5%) Median serum sodium was 137mEq/l (range 115-147 mEq/l) and hyponatremia frequency was 17.2% (10/58).
On univariate analysis, three independent variables increased the risk of hyponatremia: age more than 65 (OR 16.5 p=0.001), adrenal insufficiency (OR 5.133 p=0.031) and empty sella (OR 5.7 p=0.018). Gender and thyroid status were not predictive variables.
On multivariate analysis, age more than 65 years old (OR 8.437 p=0.02) and empty sella (OR 6.204 p=0.046) remained significant but low serum cortisol level did not show a significant statistic association (OR 3.75 p=0.172).
Conclusion: We suggest, that both patients, over 65 years old and those suffering from an empty sella had an increased risk of hyponatremia in this series. Low serum cortisol level might be another predictive variable but a major sample size should be required.
Nothing to Disclose: MGJ, JMF, APL, KM, MWV, CG, MCP, MK
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