Session: SAT 414-428-Thyroid Neoplasia & Case Reports
Poster Board SAT-420
Initially, the thyroid nodule was regarded as metastatic colon cancer. However, he was diagnosed with thyroid medullary carcinoma by fine needle aspiration biopsy cytology. Serum calcitonin level was elevated 17.3pg/mL (normal range 0-10pg/mL) and serum CEA was 29.31ng/mL (normal range 0-4.7ng/mL). RET proto-oncogene mutations were not detected. Total thyroidectomy and bilateral central neck dissection were performed.
Cut sections revealed a well circumscribed round gray-tan nodular mass, measuring 1.5x1.2cm. There is an ill defined white solid mass with central irregular yellow necrosis, measuring 0.8x0.7cm. Histological examination and Immunohistochemical stains revealed metastatic colonic adenocarcinoma in medullary carcinoma of thyroid.
Malignant metastases are rarely found in the thyroid gland, the incidence reaching approximately 2% of all thyroid malignant neoplasms. They are most often caused by tumours of the kidneys, lungs, mammary glands, ovary, and colon or by melanomas. But, tumor to tumor metastasis to thyroid cancer is extremely rare. To our knowledge, only several cases have reported in the literature(The donor tumor cells infiltrated the substance
of the follicular variant of papillary thyroid carcinoma). The present patient is the first case of colorectal carcinoma metastazing to medullary carcinoma of thyroid.
Nothing to Disclose: JM, SK, CHK, KYL
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