Session: SAT 786-805-Diabetes & Obesity Therapeutics
Bench to Bedside
Poster Board SAT-802
¹ Diabetes Centre, Royal Prince Alfred Hospital, Sydney, NSW, Australia
²Riyadh Armed Force Hospital, Riyadh, Kingdom of Saudi Arabia
3Discipline of Medicine, University of Sydney, Sydney, NSW, Australia
Aim: To compare the clinical characteristics and case fatality on Type 2 diabetes diagnosed between the age of 15–30 years to those diagnosed between 40–50 years of age, after matching for duration of diabetes.
Methods: Data of 354 patients with young onset Type 2 diabetes collected over 20 years were compared to 1062 matched individuals with older onset Type 2 diabetes. Case fatality was evaluated by cross-referencing against the National Death Index. Further comparison was made between the deceased and the survivors of the young onset patients.
Results: Young onset Type 2 diabetes died at an earlier age than their older onset counterpart, at a disadvantage of 16 years and after the same duration of diabetes, usually from vascular disease (50%, p=0.0001). Despite their younger age, they were equally affected by features of the metabolic syndrome when compared with the older onset individuals but were less treated for hypertension and dyslipidaemia (p<0.0001). There was no difference in the updated HbA1c and retinopathy between the two groups. However, the younger group had more albuminuria (p=0.01) and neuropathy (p=0.002). The deceased young onset individuals could not be distinguished from the survivors by any clinical criteria at their first visit but at the last visit before death, the deceased group had more albuminuria, hypertension, peripheral artery disease and stroke (p=0.01).
Conclusion: We conclude that individuals with young onset Type 2 diabetes suffer at least a 16 years excessive loss in life expectancy. Their cardiovascular risk factors should be treated more intensively.
Nothing to Disclose: AHA, MC, LM, FG, FG, CL, TW, SMT, DY, JW
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