The Effect of Vitamin D Supplementation on Health-Related Quality of Life Among Patients with Low Vitamin D

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 238-262-Vitamin D Action, Deficiency & Disorders
Bench to Bedside
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-254
Odessa Tolentino Wilson*1 and Carolyn Navarcan Montano2
1Makati Medical Center, Makati City, Philippines, 2Makati Medical Hospital, Makati, Philippines
BACKGROUND: Vitamin D deficiency was flagged as a major health concern in South Asia(2). Aside from bone-related problems, patients may present with nonspecific signs and symptoms, sometimes, complicating management of some diseases. A level ≤  20 ng/ml is considered as Vitamin D Deficiency while a level of 21-29 ng/ml is considered as Vitamin D insufficiency(1).

OBJECTIVE: To determine the effect of Vitamin D level on Health-realted Quality of Life (HRQoL).

METHODS: The study was a prospective cohort that included 76 patients from Makati Medical Center (MMC), Philippines, with a baseline Vitamin D level below 30ng/ml who were prescribed with Vitamin D supplementation between 2000 IU to 6000 IU daily for eight weeks.  Included patients answered the FACIT system questionnaire on Functional Assessment of Non-life threatening (FANLT) conditions (5) at baseline and after 8 weeks of Vitamin D supplementation.

RESULTS: The increase in  Vitamin D level from baseline to 8 weeks was significant (p-value <0.0001). Physical well-being (PWB), Social and Family well-being (SFWB), Emotional well-being (EWB), Functional well-being (FWB) and total HRQoL scores all increased from baseline and after 8 weeks and were all significant (p-value <0.0001). Vitamin D level at the start of the study and  the total HRQoL score of the patients showed significant correlation (r=0.2599, p-value = 0.0234). But when analyzed separately, only PWB showed significant correlation with Vitamin D levels at the start of the study (r= 0.2241, p-value of=0.0561). The results after 8 weeks showed significant  correlation in  the improvement of Vitamin D level in  percent change from baseline, with regards to the improvement in PWB, SFWB, and total HRQoL (r = 0.2310, p-value = 0.0447; r = 0.3643, p-value= 0.0012; r= 0.2560,  p-value = 0.0256, respectively). However, EWB did not show correlation with improvement in Vitamin D level while FWB showed negative correlation ( r= 0.0034, p-value of 0.1342, r= -0.1734, p-value 0.9764, respectively).

CONCLUSION: This study showed that when Vitamin D deficiency or insufficiency was corrected, there was indeed a positive effect on physical, social and family well-being and overall  HRQoL of patients. The result of this study suggests benefit in achieving a normal Vitamin D level in improving quality of life of patients.

(1) Holick, et al. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline. JCEM 2011; 1911-1930. (2) Widespread vitamin D deficiency a concern in Asia. 2011 International Osteoporosis Foundation  - Last Editorial Review, January 2011. (3) Fauci, et, al., Harrison’s Principle of Internal Medicine 17th edition. (4)Melmed, et al, Williams Textbook of Endocrinology 12th edition. (5) FACIT measurement system: Functional Assessment of Non-life threatening conditions (FANLT) questionnaire (6) Merlo, C. et.al. Prevalence and symptoms of Vitamin D deficiency in general practice. Praxis (Bern 1994). 2012 Oct 31;101(22):1417-22. (7) Pathak, S. Case-series. Endocrine Society 94th annual meeting, Houston, Texas. (8) Huang, W. et.al., Improvement of Pain, Sleep, and Quality of Life in Chronic Pain Patients With Vitamin D Supplementation. Clin J Pain. 2012 Jun 13.

Nothing to Disclose: OTW, CNM

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