Session: MON 238-262-Vitamin D Action, Deficiency & Disorders
Bench to Bedside
Poster Board MON-254
OBJECTIVE: To determine the effect of Vitamin D level on Health-realted Quality of Life (HRQoL).
METHODS: The study was a prospective cohort that included 76 patients from Makati Medical Center (MMC), Philippines, with a baseline Vitamin D level below 30ng/ml who were prescribed with Vitamin D supplementation between 2000 IU to 6000 IU daily for eight weeks. Included patients answered the FACIT system questionnaire on Functional Assessment of Non-life threatening (FANLT) conditions (5) at baseline and after 8 weeks of Vitamin D supplementation.
RESULTS: The increase in Vitamin D level from baseline to 8 weeks was significant (p-value <0.0001). Physical well-being (PWB), Social and Family well-being (SFWB), Emotional well-being (EWB), Functional well-being (FWB) and total HRQoL scores all increased from baseline and after 8 weeks and were all significant (p-value <0.0001). Vitamin D level at the start of the study and the total HRQoL score of the patients showed significant correlation (r=0.2599, p-value = 0.0234). But when analyzed separately, only PWB showed significant correlation with Vitamin D levels at the start of the study (r= 0.2241, p-value of=0.0561). The results after 8 weeks showed significant correlation in the improvement of Vitamin D level in percent change from baseline, with regards to the improvement in PWB, SFWB, and total HRQoL (r = 0.2310, p-value = 0.0447; r = 0.3643, p-value= 0.0012; r= 0.2560, p-value = 0.0256, respectively). However, EWB did not show correlation with improvement in Vitamin D level while FWB showed negative correlation ( r= 0.0034, p-value of 0.1342, r= -0.1734, p-value 0.9764, respectively).
CONCLUSION: This study showed that when Vitamin D deficiency or insufficiency was corrected, there was indeed a positive effect on physical, social and family well-being and overall HRQoL of patients. The result of this study suggests benefit in achieving a normal Vitamin D level in improving quality of life of patients.
Nothing to Disclose: OTW, CNM
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