Session: MON 776-795-Cardiometabolic Risk & Vascular Biology
Poster Board MON-785
Methods: This population-based study included 104 subjects with normal glucose tolerance and 104 subjects with new onset T2D. Their serum irisin and adiponectin levels and metabolic parameters were measured. The serum irisin levels of two groups were compared. Multivariate logistic regression analysis was performed to assess the association between irisin and development of T2D.
Results: Serum irisin levels were significantly decreased in new onset T2D group compared with NGT control group (p =0.003). Serum irisin levels correlated negatively with BMI(p = 0.027), 2h OGTT glucose (p=0.003), HbA1c (p = 0.026) and triglyceride (p = 0.033) but it did not correlated with other metabolic parameters. Multiple regression analysis showed that 2h OGTT glucose was independent variable influencing serum irisin levels (p=0.004). Furthermore, in a multivariable model adjusted for BMI, eGFR, DBP, hip and HOMA-IR, increase in irisin levels were associated with reduced odds (OR 0.64, 95% CI 0.47-0.88, p = 0.006) of incident of T2D.
Conclusion: In the present study, we found that serum irisin levels were decreased in T2D and associated inversely with development of T2D. This study raises the possibility that irisin may an important role in glucose intolerance and T2D.
Nothing to Disclose: YKC, KGP, IKL, JGK, JYJ, HAS, EHK, JHJ, KHB
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