Serum irisin levels in Korean patients with new onset type 2 diabetes

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: MON 776-795-Cardiometabolic Risk & Vascular Biology
Clinical
Monday, June 17, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board MON-785
Yeon-Kyung Choi*1, Keun-Gyu Park1, In-Kyu Lee1, Jung-Guk Kim1, Ji-Yun Jeong1, Hyun-Ae Seo2, Eui-Hyun Kim2, Jae-Han Jeon1 and Kwi-Hyun Bae1
1Kyungpook National University School of Medicine, 2DAEGU FATIMA HOSPITAL
Aims: Irisin has been identified as a novel myokine that drives brown-fat-like development of white adipose tissue. However, little clinical studies reported the relationship between irisin levels and the glucose tolerance. In this cross-sectional study, we have investigated whether serum irisin level is decreased in patients with type 2 diabetes (T2D) compared to normal glucose tolerance (NGT) controls. We also assessed associations between serum irisn and metabolic parameters.

Methods: This population-based study included 104 subjects with normal glucose tolerance and 104 subjects with new onset T2D. Their serum irisin and adiponectin levels and metabolic parameters were measured. The serum irisin levels of two groups were compared. Multivariate logistic regression analysis was performed to assess the association between irisin and development of T2D.

Results: Serum irisin levels were significantly decreased in new onset T2D group compared with NGT control group (p =0.003). Serum irisin levels correlated negatively with BMI(p = 0.027), 2h OGTT glucose (p=0.003), HbA1c (p = 0.026) and triglyceride (p = 0.033) but it did not correlated with other metabolic parameters. Multiple regression analysis showed that 2h OGTT glucose was independent variable influencing serum irisin levels (p=0.004). Furthermore, in a multivariable model adjusted for BMI, eGFR, DBP, hip and HOMA-IR, increase in irisin levels were associated with reduced odds (OR 0.64, 95% CI 0.47-0.88, p = 0.006) of incident of T2D.

Conclusion: In the present study, we found that serum irisin levels were decreased in T2D and associated inversely with development of T2D. This study raises the possibility that irisin may an important role in glucose intolerance and T2D.

Nothing to Disclose: YKC, KGP, IKL, JGK, JYJ, HAS, EHK, JHJ, KHB

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm