Session: FP28-Thyroid Autoimmunity
Room 103 (Moscone Center)
Poster Board SUN-434
Methods: TSAb levels were measured with a commercial bioassay that uses a chimeric TSH-R and a CRE-dependent luciferase. TSAb results were expressed as percentage of specimen-to-reference ratio (SRR%). Values ≥140% were considered positive. Samples of children with GD, type 1 diabetes (T1D) and healthy controls (C) were measured for thyroid binding inhibiting immunoglobulins (TBII, automated electrochemiluminescence immunoassay).
Results: A total of 164 sera samples were obtained from 85 GD children (73 female, mean age ± SD 14.24 ± 3.9 years, 40 children with GD/GO). Sera from 50 euthyroid controls (27 female, 12.4 ± 4.3 yrs.) and 50 with T1D (23 female, 13.69 ± 3.7 yrs.) were included. TSAb and TBII were detected in 148/164 (90%) and 138 (84%) samples, respectively (p<0.001). In untreated children, TSAb and TBII were present in 54/57 (95%) and 48/57 (84%) samples, respectively (p<0.001). Also, median TSAb levels were markedly higher in untreated children with GD/GO vs. those with GD, only (SRR% 470 vs. 372, p=0.002). During antithyroid drug treatment, children with GD/GO who became euthyroid still had very high median TSAb levels compared with children with GD, only (SRR% 451 vs. 226, p<0.001). In line with this, TSAb were highly prevalent in treated children with GD/GO (57/58, 98%) vs. in GD only (37/48, 77%, p<0.001). TSAb serum levels were higher in female than in male children with GD/GO (SRR% 474 vs. 381, p=0.02). Median TSAb serum levels in children less than 12 years were higher than those >12 yrs. (SRR% 466 vs. 418, p<0.001). All children with T1D and C were TSAb (SRR% 45 and 42) and TBII negative (both 0.5 IU/L).
Conclusions: Serum TSAb levels are a biomarker of disease severity and extrathyroidal manifestations in pediatric GD.
Disclosure: GJK: Researcher, QUIDEL, CA, USA, Consultant, QUIDEL, CA, USA. Nothing to Disclose: TD, ATB, MN, MS, MK, KAP
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