Session: SUN 88-129-Acromegaly & Prolactinoma
Poster Board SUN-126
Materials and methods: 110 acromegalic patients were included in this retrospective multicentric study. An evaluation of their diagnostic 3.0T MRI was performed in order to determine the following characteristics of the adenoma: T2-weighted signal (defined by comparison with the normal pituitary tissue and only when the latter was not visualised, with the cerebral grey matter), vertical extrasellar extension, lateral invasion of the cavernous sinus, maximum diameter. IGF1 value at diagnosis was also retained as a ratio from the superior normal laboratory limit for age and sex.
Results: Of the 110 pituitary GH-secreting adenomas reviewed, 67,3% were T2 hypointense and 32,7% hyperintense. The age at diagnosis was significantly lower in men compared to women (P=0,01). More than half of the GH-secreting adenomas manifest a proclivity for infrasellar extension, independent of T2-signal. Hypointense T2 adenomas compared to the hyperintense ones invade less the cavernous sinus (P=0,04), are associated with higher IGF1 levels (P=0,01) and tend to be smaller (P=0,07).
Conclusions: Our study establishes the first 3.0T MRI description of the typical features of GH-producing adenomas at the diagnosis of acromegaly on an important number of patients. These adenomas are more frequently hypointense on T2-weighted MRI and, irrespective of their signal, are associated with a younger age at diagnosis in men than in women and present a tendency towards infrasellar extension. T2-hypointense adenomas generally do not invade the cavernous sinus, are associated with a higher production of GH as proven by the higher IGF1 levels and are smaller than their hyperintense counterparts. These observations support the importance of T2-signal description of GH-producing pituitary adenomas and incite towards further studies that could evaluate the prognostic value of the radiologic characterization.
Nothing to Disclose: IP, PP, FS, GR, FC, AB, SG, LT, AB, JFB
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