Adiposity in Youth with Type 1 Diabetes Compared with a Normative Sample of Youth from NHANES

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SUN 758-779-Cardiometabolic Risk & Vascular Biology
Clinical
Sunday, June 16, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SUN-776
Charu Baskaran*1, Suzanne S Mickey1, Lisa K Volkening1, Tonja R Nansel2, Leah M Lipsky2, Sanjeev N Mehta1 and Lori M Laffel1
1Joslin Diabetes Center, Boston, MA, 2Eunice Kennedy Shriver National Institute of Child Health & Human Development, Bethesda, MD
Youth with type 1 diabetes (T1D) have similar rates of overweight and obesity as found in the general pediatric population, amounting to 1/3 of youth; however, comparisons of adiposity between T1D and NHANES youth are warranted.

We assessed adiposity, expressed as percent body fat (%BF), in youth with T1D and compared adiposity with age-matched youth from NHANES (1999-2004). Adiposity, measured by Dual-energy X-ray Absorptiometry (DXA, Hologic Delphi™ A), a gold standard method, was obtained in 126 youth with T1D. T1D youth (49% male, 89% white) were 12.9±2.5 (mean±SD) years old and had T1D duration of 5.9±3.2 years; 72% received insulin pump therapy and A1c was 8.1±1.1%. Females with T1D had significantly higher %BF than males with T1D (30.2±6.8% vs. 25.5±8.3%, p=.0003), similar to the sex differences reported in NHANES youth (females vs. males: 32.6±9.5 vs. 25.7±10.3, p<.0001).

We categorized the youth with T1D along with the NHANES sample into 3 age groups, representative of pre-pubertal (8-11.4 years), pubertal (11.5-13.9 years), and post-pubertal (14-17 years) status. Within each age group, we compared %BF between T1D and NHANES youth separately for males and females using unpaired t tests.

In youth aged 8-11.4 years, T1D males (n=17) had lower %BF than NHANES males (n=915) (24.1±5.4 vs. 27.9±9.8, p=.01); T1D females (n=23) trended towards lower %BF than NHANES females (n=921) (28.7±7.9 vs. 32.2±9.7, p=.09). In youth aged 11.5-13.9 years, T1D males (n=24) had similar %BF to NHANES males (n=1015) (29.9±9.1 vs. 27.4±11.8, p=.30); T1D females (n=17) had lower %BF than NHANES females (n=1053) (29.0±5.7 vs. 32.0±9.8, p=.05). In youth aged 14-17 years, T1D males (n=21) trended towards lower %BF than NHANES males (n=1528) (20.6±6.6 vs. 23.3±9.7, p=.08); T1D females (n=24) had similar %BF to NHANES females (n=1443) (32.7±6.0 vs. 33.3±9.3, p=.64).

Males with T1D appear to have lower adiposity than males in NHANES except during the pubertal years when their adiposity appears similar. Females with T1D appear to have lower adiposity than females in NHANES during the pre-pubertal and pubertal years. The lower adiposity in younger T1D females compared to NHANES females appears to wane in the post-pubertal years when females with T1D and NHANES females have similar adiposity. Females with or without T1D appear to gain adiposity, measured as %BF, during adolescence in contrast to males with or without T1D who appear to gain muscle mass.

Disclosure: LML: Advisory Group Member, Bristol-Myers Squibb, Advisory Group Member, Sanofi, Consultant, Johnson &Johnson, Consultant, LifeScan/Animas, Consultant, Eli Lilly & Company, Consultant, Menarini. Nothing to Disclose: CB, SSM, LKV, TRN, LML, SNM

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm

Sources of Research Support: NICHD contract HHSN267200703434C; NIH Training Grant 5 T32 DK007260-36