FP31-6 The effect of vitamin D-supplementation on insulin sensitivity in non-western immigrants in the Netherlands: A randomized placebo-controlled trial

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: FP31-Disorders of Vitamin D Metabolism & Action
Monday, June 17, 2013: 10:45 AM-11:15 AM
Presentation Start Time: 11:10 AM
Room 130 (Moscone Center)

Poster Board MON-240
Mirjam Oosterwerff*1, Elisabeth Maria Willemina Eekhoff2, Natasja Van Schoor3, Joan Boeke4, Prabath Nanayakkara3, Rosa Meijnen3, Dirk L Knol5, Mark Kramer3 and Paul Lips6
1VU Medical Centre, Amsterdam, Netherlands, 2VU Med Centrum, Amsterdam, Netherlands, 3Vu Medical Center, 4General practioner, Amsterdam, 5VU University Medical Center, 6VU University Medical Centre, Amsterdam, Netherlands
Context: Low serum 25-hydroxyvitamin D [25(OH)D] levels have been associated with insulin resistance, the metabolic syndrome and type 2 diabetes mellitus. Because many non-western immigrants in the Netherlands are vitamin D deficient, obese and at high risk for diabetes mellitus, vitamin D supplementation may contribute to prevent diabetes mellitus and insulin resistance.

Objective: To examine the effect of vitamin D supplementation on insulin sensitivity and β-cell function in overweight, vitamin D deficient non-western immigrants at high risk of diabetes.

Design & Setting: Randomized, single-center, double-blind, placebo-controlled trial. (Trialregister.nl registration number: NTR1827) at the Clinical Research Unit, Department of Internal Medicine, VU University Medical Center, Amsterdam.

Participants: 130 non-western immigrants with pre-diabetes (fasting glucose > 5.5 mmol/l or random glucose 7.8 mmol/l-11.1 mmol/l) and vitamin D deficiency (serum 25[OH]D < 50 nmol/l) were randomly assigned after stratification by sex.

Intervention: Cholecalciferol (1200 IU once daily) or placebo. All participants received calcium 500 mg per day as calcium carbonate for 16 weeks.

Main Outcome Measure: The primary outcome was the difference in area under the curve of insulin and glucose after a 75 gram oral glucose tolerance test after four months treatment. Secondary outcomes were insulin sensitivity parameters, β-cell function parameters and body mass index.

Results: Mean serum 25(OH)D levels increased significantly in the vitamin D group compared to the placebo group. After 4 months therapy, the mean between-group difference was 38 nmol/l [95% CI, 32.1-43.9]; p<0.001. There was no significant effect on insulin sensitivity and β-cell function.

Conclusions: Vitamin D supplementation in non-western vitamin D deficient immigrants with pre-diabetes did not improve insulin sensitivity or improve β-cell function.

Nothing to Disclose: MO, EMWE, NV, JB, PN, RM, DLK, MK, PL

*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm

Sources of Research Support: ZonMw
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