Session: FP31-Disorders of Vitamin D Metabolism & Action
Room 130 (Moscone Center)
Poster Board MON-240
Objective: To examine the effect of vitamin D supplementation on insulin sensitivity and β-cell function in overweight, vitamin D deficient non-western immigrants at high risk of diabetes.
Design & Setting: Randomized, single-center, double-blind, placebo-controlled trial. (Trialregister.nl registration number: NTR1827) at the Clinical Research Unit, Department of Internal Medicine, VU University Medical Center, Amsterdam.
Participants: 130 non-western immigrants with pre-diabetes (fasting glucose > 5.5 mmol/l or random glucose 7.8 mmol/l-11.1 mmol/l) and vitamin D deficiency (serum 25[OH]D < 50 nmol/l) were randomly assigned after stratification by sex.
Intervention: Cholecalciferol (1200 IU once daily) or placebo. All participants received calcium 500 mg per day as calcium carbonate for 16 weeks.
Main Outcome Measure: The primary outcome was the difference in area under the curve of insulin and glucose after a 75 gram oral glucose tolerance test after four months treatment. Secondary outcomes were insulin sensitivity parameters, β-cell function parameters and body mass index.
Results: Mean serum 25(OH)D levels increased significantly in the vitamin D group compared to the placebo group. After 4 months therapy, the mean between-group difference was 38 nmol/l [95% CI, 32.1-43.9]; p<0.001. There was no significant effect on insulin sensitivity and β-cell function.
Conclusions: Vitamin D supplementation in non-western vitamin D deficient immigrants with pre-diabetes did not improve insulin sensitivity or improve β-cell function.
Nothing to Disclose: MO, EMWE, NV, JB, PN, RM, DLK, MK, PL
*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm
See more of: Abstracts - Orals, Featured Poster Presentations, and Posters