Session: OR17-Diabetes: New Diagnostic & Treatment Modalities
Room 307 (Moscone Center)
Method: In this retrospective analysis, FPG and/or 2hrG from OGTT were available from 2994 Baltimore Longitudinal Study of Aging (BLSA) subjects (Male = 1775, 59.3%; average number of visits = 4.5 ± 4.3) from 1964 to 2012. Subjects were diagnosed with prediabetes or diabetes using the 2011 American Diabetes Association diagnostic criteria2. Of the 2994 subjects, 1085 subjects developed prediabetes and 410 subjects developed type 2 diabetes during one of their follow-up visits while the glucose tolerance of 1499 subjects remained normal during their last follow-up visits. We assessed the retrospective trajectories of FPG and 2hrG for up to 45 years before the diagnosis of diabetes, prediabetes, or at the last follow-up visit for the healthy group. ANCOVA was used to compare the differences among the 3 groups.
Results: The age of diagnosis was significantly different (P<0.001) among the three groups: 60±19, 59±16, and 66±12 yrs, for healthy, prediabetes, and diabetes group respectively. Analysis of covariance adjusted for the age at diagnosis revealed that compared to the healthy group, the diabetes group had significantly higher FPG and 2hrG at least 32 and 27 years, respectively, prior to diagnosis (P < 0.05). The prediabetes group when compared to the healthy group has significantly higher FPG and 2hrG at least 14 and 5 years, respectively, prior to diagnosis (P < 0.05).
Conclusion: In this study of BLSA subjects, we found that the changes in FPG and 2hrG occurred at least 25 to 30 years prior to the diagnosis of diabetes, and at least 5 to 15 years prior to the diagnosis of prediabetes. Thus, much earlier screening and intervention in high-risk individuals are needed to deter the development of diabetes.
Nothing to Disclose: DDL, JPD, LF, JME, CWC
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