Session: MON 758-775-Beta Cells, Glucose Control & Complications
Poster Board MON-765
Methods: This cross-sectional analysis used data from 1185 subjects (49.7% men) who participated in the Baltimore Longitudinal Study of Aging with fasting plasma glucose (FPG) < 126 mg/dL or 2-hr plasma glucose from 75-gm oral glucose tolerance test (2hrG) < 200 mg/dL. Using multiple linear regression analysis, we tested the association between A1c and fasting plasma leptin levels adjusting for age, sex, BMI, FPG, and 2hrG. Leptin was log transformed for analyses. Data are presented as mean ± SE, except for leptin which was presented as median (interquartile range), and standardized regression coefficients (β) were used.
Results: The population characteristics are as follows: age = 68±14 yrs; BMI = 27±5 kg/m²; A1c = 5.74 ± 0.46 %; FPG = 95.5 ± 10.3 mg/dl; 2hrG = 120.0 ± 34.2mg/dl; and leptin = 21.29±19.97 ng/ml. Using multiple linear regression analysis, A1c was independently associated with leptin (β=0.14; P<0.001) after adjusting for age (β=0.20; P<0.001), BMI (β = -0.002, P =0.96), sex (β = -0.04, P=0.27), FPG (β =0.19; P<0.001) and 2hrG (β =0.13; P<0.001).
Conclusion: Circulating leptin levels may contribute to the age-associated increase of A1c. Further research is needed to characterize how leptin and other as yet unknown factors contribute to the increase of A1c with age, and how best to use A1c in diagnosing diabetes in the older population.
Nothing to Disclose: JPD, DDL, LF, JME, CWC
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