Session: SAT 532-553-Hyperandrogenic Disorders
Poster Board SAT-544
Thirty-two women (PCOS n=18, Control n=14) had a 2-h 75-g OGTT to exclude diabetes, an overnight polysomnogram (PSG), and blood sampling every 20 min over a 24-h period to assess adiponectin and leptin concentrations. The HOMA-IR was calculated from fasting glucose and insulin values. OSA severity was quantified by the Apnea-Hypopnea Index (AHI). All analyses were controlled for BMI, and results are shown as mean ± SE.
Both PCOS and controls were obese (BMI: 40.7±7.0 vs. 44.9±9.7 kg/m2, respectively, p=0.167). PCOS women were younger than non-PCOS women (26.6±5.9 vs. 32.9±6.5 yr, p=0.008). Twenty-eight percent of PCOS women versus 36% of control women had OSA (AHI >5 events/hour), and 33% of PCOS women versus 14% of control women had prediabetes (IFG and/or IGT). Mean 24-h adiponectin levels were lower in PCOS than non-PCOS women (PCOS OSAneg: 5.5; PCOS OSApos: 4.3; Control OSAneg: 8.4; Control OSApos: 5.6 ug/mL; p=0.005) and were inversely related to severity of OSA (p=0.019). In multiple regression analyses controlling for BMI and AHI, the expected inverse relationship between adiponectin and leptin was present in control women (p=0.003), but not in PCOS women (p=0.893). Similarly, the expected inverse relationship between adiponectin levels and HOMA-IR was present in control women (p=0.017) but not in PCOS women (p=0.491).
CONCLUSIONS: Women with PCOS have lower adiponectin levels than non-PCOS women and this difference is exacerbated by the presence and severity of OSA. Contrary to control women, adiponectin levels in PCOS women are not related to leptin levels and do not correlate with fasting insulin resistance. Low adiponectin levels in PCOS women, particularly those with OSA, may play a role in their increased risk of cardiometabolic dysfunction.
Nothing to Disclose: KAT, RL, HW, BM, EV, DAE
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