Session: SAT 224-247-Osteoporosis I
Poster Board SAT-241
Silmara Gusso, PhD1, Craig F Munns MD2, Wayne Cutfield MD1, Paul Hofman MD1.
1 Liggins Institute, University of Auckland, Auckland, New Zealand.
2 Children’s Hospital Westmead, University of Sydney, Sydney, Australia.
Introduction: Reduced muscle mass and function contributes to reduced mobility in individuals with cerebral palsy (CP) and is the primary cause of low bone mineral density (BMD), fragility fracture and bone pain. Improvement in muscle function with physiotherapy is limited and there are currently no non-invasive therapies that improve bone health in CP adolescents. Aims: We aimed to investigate the effect of whole body vibration therapy (WBVT) on muscle function and bone health in a group of adolescents (10-20 years) with moderate CP in the Auckland area. Methods: 13 adolescents, aged 10-20 years were recruited. Assessments were performed before and after 20 weeks of WBVT. Total body, femur and lumbar spine composition were determined using dual X-ray absorptiometer (DEXA) scan. Peripheral quantified computer tomography (pQCT) was used to determined tibial vBMD, BMC and muscle CSA at three sites. Muscle function was assessed using a 6 minute walk test. The Leonardo force plate was used to assess jump force and power, balance and chair raise. WBVT was performed 4 days per week for 20 weeks using the GalileoTM Home vibration platform. Sessions lasted 18 min daily (3 minutes vibration followed by 3 minutes rest- repeated 3 times). Results: The study group consisted of 8 females and 5 males with mean age 16.8 ± 2.2 years. Although total body (TB) BMD did not increase after intervention, total leg (p=0.02) and spine (p=0.02) BMD increased. No differences in trunk or pelvis BMD, fat % or TB lean mass were observed after intervention. The mean distance covered during the 6 minute walk test improved 286 ± 155 m to 314 ± 165 m (p=0.002). On pQCT, muscle cross sectional area at the 50% tibial site increased from 3163 ± 548 mm2 to 3440 ± 686 mm3 (p=0.02). Volumetric BMD at the 20% tibial site increased from 606.9 ± 160.4 mg/cm3 to 689.6 ± 233.7 mg/cm3 (p=0.02). Conclusion: WBVT showed significant improvements in motor function and BMD in adolescents with CP. By improving muscle mass and bone mineral accrual during growth; WBVT can optimise mobility and bone strength into adult life.
Sources of support: The Jubille Trust.
Nothing to Disclose: SG, CFM, WSC, PLH
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