Session: SUN 88-129-Acromegaly & Prolactinoma
Poster Board SUN-129
We conducted a retrospective study including children and adolescents harboring prolactinomas followed at our Neuroendocrine Unit.
Methods: A retrospective study to evaluate hyperprolactinemia in patients up to 20 yrs-old with symptoms related to increase prolactin levels was performed. Hospital records as clinical features at presentation, prolactinoma size, medical treatment outcomes and surgical results were analyzed.
Results: Thirty nine patients were included in the study, and except for 3 patients with macroprolactinemia, all others presented prolactinomas: 77.8% were females. They included 28 (77.8%) macroprolactinomas (MAC), 8 (22.2%) microprolactinomas (MIC) and 3 cases of MEN1 amongst patients with MAC (2 women). Surgery was performed in 16 (44.4%) patients (2 MIC and 14 MAC, 12 women and 4 men) due to dopamine agonist resistance in 9 patients, dopamine agonist intolerance in 5 patients, and apoplexy in 2 patients (one of them during pregnancy). Four cases presented tumor remission after surgery and five cases needed two surgeries. Panhypopituitarism was already present in 20% at the diagnosis and in additional 12.5% of patients after surgery. In two cases, hormonal deficiencies were reverted during dopamine agonist treatment.
Twenty eight patients were treated with bromocriptine (46.4% intolerant), and thirty three patients were treated with cabergoline (9.1% intolerant). Five % of cases presented intolerance to both dopaminergic agonists. In five patients (13.9%) normoprolactinemia was maintained after dopamine agonist withdrawal.
Conclusions: In this study, we confirmed literature data about prolactinoma aggressiveness in children and teenagers. The high rate of surgical treatment was due to a high percentage of dopamine agonist resistance/intolerance in this group of patients
Nothing to Disclose: TDPS, AG, CF, VASC, NM, MC, MDB
*Please take note of The Endocrine Society's News Embargo Policy at http://www.endo-society.org/endo2013/media.cfm
See more of: Abstracts - Orals, Featured Poster Presentations, and Posters