Session: SUN 554-573-Ovarian & Uterine Function I
Poster Board SUN-565
Purpose: To describe POF/POI symptoms within a non-clinic-based sample of women subscribing to the International Premature Ovarian Failure Association (IPOFA) website.
Methods: 290 women were surveyed via the IPOFA list serve over 6-weeks. The survey included demographics, health history, the Menopause-specific Quality of Life Questionnaire (MenQOL), ten additional symptoms (reviewed by women with POF/POI for face validity), and free-text for comments. Women providing a date of birth and age at diagnosis < 40 were included in all analyses. Categorical (frequency, %) and continuous (with mean +/-SD, or median and IQR) variables were summarized appropriately. Pearson correlation of symptom count with MenQOL score was assessed.
Results: 160 women ages 18-63 (mean age 39.3 [SD 7.3]) were included (55% response). Age at diagnosis ranged from 10-39, median 30 (IQR: 24-35). Most respondents were white, had at least a bachelors degree and were employed full time. 43% of the respondents reported a history of depression, 25% of whose episode occurred more than 5 years before their POF/POI diagnosis. Women reported a mean of 14.7 (SD 7.4) out of 29 MenQOL symptoms; the correlation of each of 4 MenQOL domain scores and time since diagnosis, current age and age at diagnosis was weak (all ρ <|0.25|). Other common symptoms included mood swings and mental fog (>75%); hair loss, dry eyes, cold intolerance and joint clicking (>50%), followed by tingling in limbs and low blood pressure (app 33%), hypothyroidism (17%), hypoglycemia (16%) and gluten allergies (10%). 90 unique symptoms were written in an “other symptoms” field; 58% included a personal story, 27% described HRT experience and 18% gave questionnaire feedback.
Conclusions: Symptom checklists created for age-appropriately menopausal women do not adequately capture the scope of symptoms we observed in this sample. Menopausal symptoms do not appear to diminish over time in women with POF/POI, in contrast to women with age-appropriate menopause. The relationship between depression and POF/POI may be bidirectional, with some women clearly experiencing depression well before their diagnosis. Hypothyroidism in our sample is >3x the national mean. Mood, symptom and fertility questions specific for women with POF/POI are needed.
Nothing to Disclose: AAA, AS
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