Session: SUN 130-162-Neuroendocrinology
Poster Board SUN-150
Objectives and Patients: In a cohort of 82 acromegalic patients, correlate BMD and bone microarchitecture, using dual-energy X-ray absorptiometry (DXA) and high-resolution peripheral quantitative computed tomography (HR-pQCT), with the presence of type 2 diabetes mellitus (T2DM), disease activity and gonadal status. To compare these bone parameters between 45 eugonadal acromegalic patients and 45 healthy controls.
Results: Acromegalic patients with T2DM had lower trabecular density (Dtrab) and trabecular bone volume to tissue volume (BV/TV) ratio in the distal tibia. Patients with active acromegaly exhibited a higher BMD and T-score in the lumbar spine (p=0.02 for both) and a higher cortical density in the distal tibia when compared to those with controlled acromegaly (p=0.001). After multiple linear regression (including age, presence of T2DM, acromegaly activity and gonadal status), eugonadism remained the main determinant of bone parameters. The 45 acromegalic patients with eugonadism were compared with 45 age- and sex-matched controls and exhibited lower trabecular densities and impaired microstructures.
Conclusions: Acromegaly appears to have a deleterious effect on trabecular bone microarchitecture and that, in this specific population, the gonadal status might be more important than T2DM or acromegaly activity in determining bone health. HR-pQCT seems promising for evaluating acromegalic bone properties and for addressing the limitations posed by DXA.
Nothing to Disclose: MM, LVN, FDPPN, ICBL, LMCM, MG, MLFF
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