Associations Observed in Obese Women The Agra Syndrome

Program: Abstracts - Orals, Featured Poster Presentations, and Posters
Session: SAT 677-696-Obesity Physiology & Epidemiology
Saturday, June 15, 2013: 1:45 PM-3:45 PM
Expo Halls ABC (Moscone Center)

Poster Board SAT-682
Daya K Hazra*1, Padmamalika Hazra2, Arun Kumar Gupta3, Nandita Hazra1 and Prasan Gangwar1
1Boston Medical Centre, Agra, India, 2St Johns College,Agra, Agra, India, 3S N Medical College, Agra
Associations Observed in Obese Women:the Agra syndrome

Obesity is one of the commonest problems encountered in an endocrine practice.Over the last 35 years at Agra,India,we have noted that obesity in women is often attributed by such  patients to a gynaecological  operative procedure-hysterectomy or tubal ligation, chiefly on the ground that erstwhile slim figures were replaced by an obese body form .It was therefore considered appropriate to examine whether this belief had any foundation in fact.

This study is an analysis of 600 consecutive cases of obesity in women of recent onset  studied over the past three years,compared with 600 age matched nonobese women from their relatives,and the same socioeconomic groups.Obesity was defined in terms of the revised Indian BMI standards for women(Misra A,ChowbeyP,Makkar BM et al,JAPI,57,163-170,2009).Recent weight gain was defined in terms of documented weight increase over 10 kg  in the previous three years. The subjects were interrogated in relation to a)any gynaecological procedure in the six months preceding the weight gain,b)Whether this procedure was ligation or hysterectomy, c)whether any surgical procedure other than these e.g.cholecystectomy had been performed during these six months , d)whether they had undergone menopause without any surgical procedure, e)whether they had been diagnosed as suffering from diabetes or hypothyroidism by their clinicians in these 3 years.

It was observed that the frequency of a recent  gynaecological procedure was significantly higher in the obese women(361/600 subjects ) as compared to controls(132/600).The procedure was hysterectomy in 286 obese subjects and ligation in  75.The history of hysterectomy and ligation was present in 91 and 41 control subjects respectively.Postmenopausal status was also more common  in the obese group( 205/600) as compared to controls(124/600).The frequency of nongynaecological surgical procedures was not significantly different(47/600 obese and 41/600 nonobese controls).Diabetes had been diagnosed in 63% of the obese women ,as compared to 33% in the nonobese controls.Hypothyroidism had been diagnosed in 28% of the obese women as compared to 12% of nonobese controls.

This analysis shows an association between recent onset obesity and gynaecological procedures, especially hysterectomy. The nature of this association is moot. The endocrine profile of the subjects reporting weight gain after gynaecological surgery is the subject of further study.

Nothing to Disclose: DKH, PH, AKG, NH, PG

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